The Impact of Modifications on Respiratory Management of Preterm Infants on the Death or Bronchopulmonary Dysplasia Outcome
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Manuel Sanchez Luna
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- BRONCHOPULMONARY DySPLASIA
Study Overview
Brief Summary
This observational study evaluates the impact of respiratory management modifications implemented in our institution on the intubation rates and the death or Bronchopulmonary Dysplasia (BPD) outcome.
Detailed Description
Less invasive respiratory management has been implemented in most neonatal units as well as lung protective ventilatory strategies when intubation is required in order to minimize ventilator induced lung injury.
In our institution a new ventilatory protocol including less invasive surfactant administration, Synchronized nasal positive pressure ventilation and early rescue High frequency ventilation has been implemented during 2013-14.
Hypothesis
New less invasive and lung protective strategies to prevent lung injury had been effective in reducing intubation rates.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- — to 36 Weeks (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All preterm Infants born with less than 32wGA admitted in our NICU.
Exclusion Criteria
- •Congenital malformations and Known Chromosomal disorders,
Outcomes
Primary Outcomes
BRONCHOPULMONARY DySPLASIA
Time Frame: 36 weeks of postmenstrual age.
Diagnosis of moderate-severe bronchopulmonary dysplasia (physiological definition)
mortality
Time Frame: before discharge
death
Secondary Outcomes
- Mechanical ventilation(during hospitalization)
Investigators
Manuel Sanchez Luna
Head of Neonatology, Clinical Professor
Hospital General Universitario Gregorio Marañon