Respiratory Adaptations to Behavioral Interventions in Elevated Blood Pressure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Breathing Rate
研究概览
简要总结
The purpose of this study is to investigate the nature of the physiological reasons for the decreases in resting blood pressure that can result from systematic practice of computer-guided breathing exercises or meditative relaxation.
详细描述
In this randomized clinical trial, persons with moderately elevated blood pressure were trained in either computer-guided breathing exercises or meditative relaxation to breathing. The computer-guided breathing exercise involves listening to tones of ascending and descending pitch to which breathing is entrained to low frequencies over a 15 minute interval. The meditative relaxation involves passive attention to natural breathing for the same duration. Participants will perform these breathing exercises daily at home for four weeks. Before and after the intervention, respiratory, cardiovascular, and urinary endogenous digitalis-like factors will be systematically recorded to determine the extent to which chronic neuroendocrine changes underlie the reductions in blood pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Over 21 years
- •Systolic blood pressure 130-160 or diastolic blood pressure 85-100
排除标准
- •More than one antihypertensive medication
- •Beta blockers, angiotensin converting enzyme inhibitors or angiotensin receptor blockers
- •History of coronary artery disease, heart failure, stroke, angina or coronary revascularization
- •Kidney disease, defined as plasma creatinine > 1.5mg/dL
- •Diabetes, defined by insulin or oral hypoglycemic medication or blood sugar > 126mg/dL
- •Pulmonary disease, defined as chronic obstructive pulmonary disease, bronchitis, asthma, or use of inhaler
- •Upper respiratory infection during past 30 days
- •Medication that affects central nervous system function
- •Steroid use
- •Current pregnancy or lactation within past six months
- •Current birth control medication or hormone replacement therapy
- •Condition that in the judgment of the Principal Investigator is incompatible with the research study
结局指标
主要结局
Breathing Rate
时间窗: After 15 minutes of guided breathing or control task
Breathing rate was monitored continuously via inductive plethysmography.
次要结局
- Minute Ventilation(After 15 minutes of guided breathing or control task)
- End Tidal CO2 (PetCO2)(After 15 minutes of guided breathing or control task)