Metabolic Adaptations to Chronic and Acute Exercise in Overweight Adults (ATX-Study)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- PPARg mRNA expression
研究概览
简要总结
The primary purpose of this study is to examine the effects of chronic exercise training and an acute session of exercise on key risk factors associated with Metabolic Syndrome (e.g., glucose tolerance, blood lipid profile, and blood pressure) and alterations in subcutaneous adipose tissue structure and metabolic function in overweight adults.
详细描述
Subjects will be asked to complete the Substrate Metabolism Laboratory General Screening Questionnaire and American Heart Association Health/Fitness Questionnaire to determine if they are eligible to complete the preliminary testing procedures. If eligible, subjects will be asked to visit the Substrate Metabolism Laboratory to participate in the preliminary testing procedures (listed below) before participating in the experimental trial.
PRELIMINARY TESTING PROCEDURES:
- Blood pressure, height and weight measurements
- Body Composition Assessment (~20 min)
- Exercise Fitness Test (~10 min)
- Resting Metabolic Rate (RMR) measurement (~30 min)
- 3 hour Oral Glucose Tolerance Test (OGTT)
EXPERIMENTAL TRIAL:
The evening before the experimental trial, subjects will eat a standardized dinner meal and snack. The meal and snack must be eaten at specific times as indicated by the research staff. After eating the snack, subjects will need to fast (no food or beverages - besides water) overnight.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 18-40
- •Body Mass Index: 25-35 kg/m2
- •Regular exercisers: (≥4 days/wk of aerobic exercise; 30-60min/session at moderate and vigorous intensities)
- •Non-exercisers: no regularly planned exercise/physical activity
- •Women must have regularly occurring menses and must be premenopausal
排除标准
- •Blood pressure > 140/90 mm Hg
- •Pregnant or lactating
- •Evidence/history of cardiovascular or metabolic disease
- •Medications known to affect lipid or glucose metabolism
结局指标
主要结局
PPARg mRNA expression
时间窗: change from baseline at 1 hour post exercise
The study team will quantify the abundance of key adipogenic markers in adipose tissue biopsy samples
Cytokine abundance in adipose tissue
时间窗: change from baseline at 1 hour post exercise
The study team will measure cytokine proteins in adipose tissue
次要结局
- Total Cholesterol(change from baseline at 1 hour post exercise)
研究者
Jeffrey F Horowitz
Professor, Movement Science; Director, Substrate Metabolism Laboratory
University of Michigan