Effect of Pitavastatin on Carotid Arteries and Aorta Evaluated by Integrated Backscatter Trans-esophageal Ultrasound and PET/CT
Not Applicable
- Conditions
- dyslipidemia
- Registration Number
- JPRN-UMIN000002151
- Lead Sponsor
- Gifu University Graduate School of Medicine
- Brief Summary
The pravastatin treatment was less effective on plaque inflammation than pitavastatin treatment. This trend was the same in the carotid arteries and the thoracic aorta. Pitavastatin not only improved the atherosis as measured by IMT and cIBS values but also attenuated inflammation of plaques as measured by max SUV at the same site. The present study indicated that pitavastatin has stronger effects on the regression and stabilization of plaques in the thoracic aorta and carotid arteries compared with pravastatin.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
familial hypercholesterolemia severe hepatic disorder or biliary atresia malignancy collagen disease renal disorder (serum creatinine >= 2.0 mg/dl) uncontrolled diabetes
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method (1) Changes of SUV evaluated by PET/CT (2) Changes of integrated backscatter values
- Secondary Outcome Measures
Name Time Method (1) Changes in lipid profile, intima-media thickness and inflammatory markers