Normative Values Laser Nociceptive Evoked Potentials Depending on the Age

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Device: laser stimulations on lower limbs; Device: laser stimulations cervical; Device: 20 laser stimulations for each site on the upper limbs; Device: laser stimulations on face and neck

• Registration Number: NCT02531048
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly.

Detailed Description

Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly. Normal values that are available have been obtained in young subjects. However, various studies have shown that the integration of nociceptive messages depended on age. The aim of this study was to establish normal values of nociceptive evoked potentials for each age group of 18 to 75 years.

Study Timeline

• Study Start: 2008-02
• Primary Completion: 2012-04
• Study Completion: 2013-12
• Study First Submitted: 2015-08-20
• Study First Submitted QC: 2015-08-20
• Study First Posted: 2015-08-21
• Status Verified: 2016-03
• Last Update Submitted: 2023-11-14
• Last Update Posted: 2023-11-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• major

Exclusion Criteria

• Neurological history
• Neuralgia history (> 3 months)
• Pathology can cause neuropathy (unbalanced thyroid dysfunction, diabetes, kidney failure, chronic hepatitis, HIV ...)
• Dermatological disorder known type of Lucite or photosensitivity
• Medical treatment analgesic, psychotropic or anti-epileptic underway
• Toxic acquired in the last 72 hours (alcohol, cannabis, other toxic ...)
• Pregnant women
• Incapacitate to stand still
• Participation in another biomedical research in the field of pain in the three months prior to inclusion.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
healthy volunteers	laser stimulations cervical	Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations : * laser stimulations on lower limbs * laser stimulations cervical * 20 laser stimulations for each site on the upper limbs * laser stimulations on face and neck
healthy volunteers	laser stimulations on lower limbs	Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations : * laser stimulations on lower limbs * laser stimulations cervical * 20 laser stimulations for each site on the upper limbs * laser stimulations on face and neck
healthy volunteers	20 laser stimulations for each site on the upper limbs	Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations : * laser stimulations on lower limbs * laser stimulations cervical * 20 laser stimulations for each site on the upper limbs * laser stimulations on face and neck
healthy volunteers	laser stimulations on face and neck	Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations : * laser stimulations on lower limbs * laser stimulations cervical * 20 laser stimulations for each site on the upper limbs * laser stimulations on face and neck

Primary Outcome Measures

Name	Time	Method
composite outcomes : latencies (ms) and amplitudes (μV) of nociceptive evoked potential	Day 0

Secondary Outcome Measures

Name	Time	Method
detection threshold (mJ/mm2)	Day 0
nociceptive threshold (mJ/mm2)	day 0

Trial Locations

Locations (1)

Chu de Saint Etienne; 🇫🇷 Saint Etienne, France