Effects of Cerebral and Peripheral Electrical Stimulation on Conditioned Pain Modulation in Healthy Subjects.
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Healthy Volunteers
- Sponsor
- Universidade Federal do Piauí
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Pressure pain threshold
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The Neuromatrix pain model and new findings on pain chronification process point to a greater efficacy of treatments that address central and peripheral rather than only peripheral structures. Both cerebral and peripheral electrical stimulations can modulate brain areas involved in pain processing. However, their effects on pain modulation systems and clinical outcomes are lacking.
This study aims to investigate the efficacy of transcranial direct current stimulation (tDCS) and peripheral electrical stimulation (PES) alone as well tDCS combined with PES on pressure pain threshold and conditioned pain modulation in healthy subjects.
Investigators
Fuad Ahmad Hazime
Assistant Professor - Physical Therapy Department
Universidade Federal do Piauí
Eligibility Criteria
Inclusion Criteria
- •Healthy subjects without medical complaints.
Exclusion Criteria
- •Concurrent medication likely to affect cognitive performance pregnancy or possible pregnancy history of drug or alcohol abuse or dependence recent head injury (in the last 3 months) history of seizure or stroke.
Outcomes
Primary Outcomes
Pressure pain threshold
Time Frame: Pre and Post-test (immediately after tDCS)
Pressure pain threshold (PPT) is defined as the minimum force applied which induces pain.
Conditioned pain modulation
Time Frame: Pre and Post-test (immediately after tDCS)
Conditioned pain modulation paradigms consist of the evaluation of a painful test stimulus followed by a second evaluation either at the same time as a distant, painful conditioning stimulus. PPT will be evaluated following a conditioning stimulus condition (hand immersion in a cold water).