Effects of Pravastatin, Phytosterols and Combination Therapy on Lipid Profile in HIV-infected Patients : An Open-labelled, Randomized Cross-over Study.
Not Applicable
Completed
- Conditions
- hypercholesterolemiaHIVPravastatinPhytosterolsHuman immunodeficiency virusLipid
- Registration Number
- TCTR20150126002
- Lead Sponsor
- Faculty of Medicine, Prince of Songkla University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
1) HIV patients aged 20 years or older whose LDL cholesterol was 130 mg/dL or higher at least 2 times in 3 months apart
2) the ARVs had not changed within the previous 6-months period
Exclusion Criteria
1) had an active opportunistic infection
2) were taking any lipid lowering agents during 2-month period before enrollment
3) had hypersensitivity to any statins
4) had transaminase enzyme 3 times higher than the upper limit of normal
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method percent LDL-c reduction of combination therapy to monotherapy 4 weeks after each intervention phase enzymatic in vitro assay for direct quantitative using MODULAR P800 analyzer
- Secondary Outcome Measures
Name Time Method percent changes of TC, TG, HDL-c and LDL-c after the first phase at 4 week after the first intervention phase enzymatic in vitro assay for direct quantitative using MODULAR P800 analyzer