ovel therapies for secretory diarrhea

Recruiting

• Conditions: ETEC infection; Traveler's diarrhea; 10017966; 10004018

• Registration Number: NL-OMON39183
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

Must be 18-55 years old.
Enrollment by informed written consent

Exclusion Criteria

Liver conditions; signs of portal hypertension
Coagulation disorders or use of anti-coagulants
(Chronic) constipation. (As this may indicate aberrant intestinal ion and fluid transport.)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The effect of 6 GC-C signaling blockers and of 4 CFTR inhibitors on the<br /><br>pro-secretory response of human colon, assessed by ICM.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The effect of 6 GC-C signaling blockers on GC-C-independent intestinal solute<br /><br>transport, assessed by ICM (off-target effects).</p><br>