The Effect of Prebiotics on Endurance Performance

Not Applicable

• Conditions: Microtia
• Interventions: Dietary Supplement: Prebiotic; Other: Placebo

• Registration Number: NCT04946578
• Lead Sponsor: Maastricht University

Brief Summary

The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.

Detailed Description

The study conforms to a randomized, single-blinded, placebo-controlled parallel study design.

a prebiotic supplement will be selected based on a participants gut microbiota. 1 sachet of prebiotic or placebo will be given twice a day over a period of 6 weeks.

Before the start of the study, a VO2max test will be performed. Subjects will bring faecal samples which is collected at home. A time to exhaustion of approximately 80% of their VO2max will be performed at baseline and after the 6 weeks intervention period.

Study Timeline

• Study Start: 2020-08-24
• Study First Submitted: 2021-05-05
• Status Verified: 2021-06
• Study First Submitted QC: 2021-06-23
• Last Update Submitted: 2021-06-23
• Study First Posted: 2021-07-01
• Last Update Posted: 2021-07-01
• Primary Completion: 2021-08-23
• Study Completion: 2021-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Male or female 18 - 40 y
• BMI range 18.5 - 25 kg/m2
• Recreational active (performing non-competitive physical endurance exercise at least two times per week with a minimum duration of 60 minutes per exercise bout)

Exclusion Criteria

• Smoking
• Performing regular resistance training (3+ times per week, carrying out progressive overload training)
• Subject following an overly imbalanced or restrictive diet as per nutritional advice
• Participants who received antibiotics in the 90 days prior to the start of the study
• Self-admitted lactose intolerance
• Administration of probiotic or prebiotic supplements in the 14 days prior to the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Prebiotic intervention group	Prebiotic	Prebiotic supplementation
Placebo control group	Placebo	Maltodextrin

Primary Outcome Measures

Name	Time	Method
Time to Exhaustion	From baseline to end of the study (up to max 45 days)	Time on cycle ergometer until exhaustion

Secondary Outcome Measures

Name	Time	Method
Insulin	From baseline to end of the study (up to max 45 days)	Fasted insulin
Plasma short chain fatty acids	From baseline to end of the study (up to max 45 days)	Short chain fatty acids in plasma
Gut microbiota composition	From baseline to end of the study (up to max 45 days)	Composition of the gut microbiota by faecal sample analysis
Blood glucose	From baseline to end of the study (up to max 45 days)	Fasted blood glucose
Intestinal permeability by sugar test	From baseline to end of the study (up to max 45 days)	Intestinal permeability measured by a sugar drink test

Trial Locations

Locations (1)

Maastricht University; 🇳🇱 Maastricht, Limburg, Netherlands