Sex Differences in Oral Bacteria
- Conditions
- Cardiovascular Disease
- Registration Number
- NCT01583803
- Lead Sponsor
- Queen Mary University of London
- Brief Summary
Females have a lower incidence of hypertensive and cardiovascular disorders that may relate to differences in nitrogen oxides in the blood and saliva. Some nitrogen oxides are recycled with the help of oral bacteria to nitric oxide which is protective against vascular disorders. This study will test the hypothesis that females have different numbers and species of these nitrogen-oxide reducing bacteria.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- Healthy subjects aged 18-45 who have volunteered themselves and are willing to sign the consent form
Exclusion Criteria
- Healthy subjects unwilling to consent
- History of hypertension, diabetes or hypertensive on BP measurement
- Pregnant, or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result
- History of any serious illnesses, including recent infections or trauma
- Subjects taking systemic medication (other than the oral contraceptive pill)
- Subjects with self-reported use of mouthwash or tongue scrapes
- Subjects with recent or current antibiotic use (within 3 months)
- Subjects with a history, or recent treatment of (within last 3 months) of any oral condition (excluding caries), including gingivitis, periodontitis and halitosis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bacterial species identification At baseline
- Secondary Outcome Measures
Name Time Method Bacterial count At baseline Blood pressure At baseline Nitrogen oxide levels in biological fluids At baseline Oral nitrate reduction At baseline
Trial Locations
- Locations (1)
William Harvey Heart Centre
🇬🇧London, United Kingdom