NCT01015794已完成不适用
Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation
Bayside Health1 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2009年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- BAT activity via PET-CT
研究概览
简要总结
In this study the investigators aim to quantitate the extent of cervical and upper thoracic brown adipose tissue (BAT) activation in lean and obese humans via positron emission tomography-computed tomography (PET-CT) in response to the non-specific beta adrenergic receptor (AR) agonist ephedrine. The investigators hypothesise that this pharmacological adrenergic stimulus will result in activation of BAT in these participants, and that this activation will be reduced in obese patients. This study will provide important preliminary information with respect to allowing the investigators to progress with longer trials with specific beta 3 AR agonists.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy group
- •Males aged 20 - 40 years
- •Free of overt coronary disease (on history, medical examination and ECG)
- •Fasting plasma glucose < 6.1 mmol/L and 2 hour OGTT glucose < 7.8 mmol/L
- •Unmedicated
- •No major illness
- •BMI 18 - 25
- •Inclusion Criteria: obese group
- •Males aged 20 - 40 years
- •Free of overt coronary disease (on history, medical examination and ECG)
- •Unmedicated
- •No major illness
- •Weight < 100 kg
- •Height < 185 cm
- •The inclusion criteria (Obese participants) of body weight less than ~100 kg is implemented as the PET-CT scanner to be utilised (protocol described subsequently) has a limited patient volume. Therefore to fit within the criteria of BMI > 30, only patients of height ~183 cm or less can be recruited, and inclusion of borderline participants will be discussed with co-investigators from the Alfred Hospital Nuclear Medicine Department.
排除标准
- •healthy group
- •Unable to give informed consent
- •Lactose intolerance
- •Exclusion Criteria: obese group
- •Unable to give informed consent
- •Lactose intolerance
- •Participant in research projects involving ionising radiation within the past 5 years
- •claustrophobia
研究组 & 干预措施
Adrenergic agonist
Experimental
干预措施: ephedrine hydrochloride (Drug)
结局指标
主要结局
BAT activity via PET-CT
时间窗: Baseline and 3 weeks
次要结局
未报告次要终点
研究者
研究点 (1)
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