Step Up Versus Step Down in Controlled Ovarian Stimulation

Phase 4

Completed

• Conditions: No Explained Sterility
• Interventions: Drug: FSH-r (Follicule stimulate hormone)

• Registration Number: NCT01376999
• Lead Sponsor: Parc de Salut Mar

Brief Summary

The aim of the study is to evaluate if the Step up protocol is equal or superior regarding efficacy and security than the step down protocol. In couple submitted two intrauterine insemination.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2011-06-17
• Study First Submitted QC: 2011-06-17
• Study First Posted: 2011-06-20
• Primary Completion: 2014-02
• Study Completion: 2014-02
• Status Verified: 2017-09
• Last Update Submitted: 2017-09-19
• Last Update Posted: 2017-09-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 158

Inclusion Criteria

• Women with unexplained sterility with needs of intrauterine insemination.

Exclusion Criteria

• Contraindications to intrauterine insemination.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Step Up	FSH-r (Follicule stimulate hormone)	Step up: We begin the COS (controlled ovarian stimulation) with 75 IU of FSH-r until 7th day of stimulation.This day we make an adjustment increasing the dose if necessary.
Step Down	FSH-r (Follicule stimulate hormone)	Step Down: We begin the COS (controlled ovarian stimulation) with 150 IU of FSH-r until 7th day of stimulation. This day we make an adjustment reducing the dose if necessary.

Primary Outcome Measures

Name	Time	Method
Ovulation rate	1 month

Trial Locations

Locations (1)

Hospital del Mar; 🇪🇸 Barcelona, Spain