Computer-Based Therapy for Mild Cognitive Impairment

Phase 1

Completed

• Conditions: Mild Cognitive Impairment

• Registration Number: NCT00319943
• Lead Sponsor: Posit Science Corporation

Brief Summary

The purpose of this study is to determine the neuropsychological and neurophysiological impacts of a computer-based training program designed to improve the cognitive performance of patients with mild cognitive impairment (MCI).

Detailed Description

The study is a randomized, double-blind, controlled trial of a computerized, cognitive intervention with three main goals: 1) to assess the magnitude of improvements in memory, language function, and cognitive function following computer training, 2) to investigate the neurophysiological mechanisms underlying such neuropsychological improvements, and 3) to demonstrate the feasibility of using this kind of computer-based therapy in older populations.

Study Timeline

• Study Start: 2004-09
• Status Verified: 2006-04
• Study First Submitted: 2006-04-27
• Study First Submitted QC: 2006-04-27
• Study First Posted: 2006-04-27
• Last Update Submitted: 2006-04-27
• Last Update Posted: 2006-04-27
• Study Completion: 2006-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

1)65 - 90 years of age 2)Meet definition for MCI including complaints of cognitive decline as indicated by patient report and/or informant report, and corroborated by clinician judgment and, the absence of dementia, defined as impairment of memory and at least one other domain of cognitive function.

3)Fluency in English 4)Willing to meet the time commitment of the study

Exclusion Criteria

1. Clinically significant cerebrovascular disease
2. Individuals scheduled to begin acetylcholinesterase inhibitor (AChEI) therapy -

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
The study investigates changes in a neuropsychological assessment battery pre-randomization
and upon the completion of training.

Secondary Outcome Measures

Name	Time	Method
Early evaluations will be conducted from brain imaging; specifically, date
obtained via positron emission tomography (PET), magnetoencephalography (MEG),
electroencephalography (EEG), and functional magnetic resonance imaging (fMRI)
studies.

Trial Locations

Locations (1)

University of California, San Francisco; 🇺🇸 San Francisco, California, United States