The effects of memantine versus placebo on visual functions of patient with optic neuritis

Phase 2

Active, not recruiting

• Conditions: isolated optic neuritis; optic neuritis; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12611000350921
• Lead Sponsor: Tehran University of Medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-04-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Isolated acute optic neuritis with duration of less than 8 days as patient declares

Exclusion Criteria

anti-convulsants, barbiturates, neuroleptics, Amantadine hydrochlorothiazids, digoxin and dextrometorphan (interacting with memantine)
Pregnancy or nursing
Renal disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
visual acuity, testing by Early Treatment Diabetic Retinopathy Study (ETDRS) chart in LogMAR (Logarithmic value for Minimum Angle of Resolution)[Baseline, 3 months after randomisation];Any change in NFL thickness measured by optical coherence tomography (OCT)[baseline, 3months after randomisation]

Secondary Outcome Measures

Name	Time	Method
Amplitudes of P waves measured by performing visual evoked potential[baseline, 3 months after randomisation]