Testosterone and Vascular Function in Reproductive-Aged Females With Chronic Kidney Disease

Completed

• Conditions: Cardiovascular Diseases; Chronic Kidney Diseases

• Registration Number: NCT06107166
• Lead Sponsor: University of Calgary

Brief Summary

Cardiovascular disease (CVD) is the leading cause of death among women and women with chronic kidney disease are at an even greater risk of CVD. The aim of this observational study is to examine the relationship between total testosterone levels and measures of vascular function (pulse wave velocity, aortic augmentation index, flow mediated dilation and velocity time integral) in reproductive-aged women living with chronic kidney disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-01
• Primary Completion: 2021-06-30
• Study Completion: 2021-12-31
• Status Verified: 2023-10
• Study First Submitted: 2023-10-24
• Study First Submitted QC: 2023-10-24
• Last Update Submitted: 2023-10-24
• Study First Posted: 2023-10-30
• Last Update Posted: 2023-10-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 61

Inclusion Criteria

• female sex
• a diagnosis of chronic kidney disease or end stage kidney disease
• age 18-51

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Exclusion Criteria

Pregnancy, breastfeeding, current use of menopausal hormone therapy or gender affirming hormone therapy, or factors that would affect ovarian function, such as polycystic ovarian syndrome, premature ovarian insufficiency, ovarian malignancy, gonadotoxic chemotherapy, surgical oophorectomy, or previous radiation to the pelvis.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aortic augmentation index	Measured at baseline
Flow mediated dilation	Measured at baseline
Pulse wave velocity	Measured at baseline
Velocity time integral	Measured at baseline

Trial Locations

Locations (1)

University of Calgary; 🇨🇦 Calgary, Alberta, Canada