Testosterone and Vascular Function in Reproductive-Aged Females With Chronic Kidney Disease

University of Calgary1 site in 1 country61 target enrollmentJune 1, 2018

ConditionsChronic Kidney Diseases Cardiovascular Diseases

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Chronic Kidney Diseases
Sponsor: University of Calgary
Enrollment: 61
Locations: 1
Primary Endpoint: Aortic augmentation index
Status: Completed
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Cardiovascular disease (CVD) is the leading cause of death among women and women with chronic kidney disease are at an even greater risk of CVD. The aim of this observational study is to examine the relationship between total testosterone levels and measures of vascular function (pulse wave velocity, aortic augmentation index, flow mediated dilation and velocity time integral) in reproductive-aged women living with chronic kidney disease.

Registry

clinicaltrials.gov

Start Date

June 1, 2018

End Date

December 31, 2021

Last Updated

2 years ago

Study Type

Observational

Sex

Female

Investigators

Sponsor

University of Calgary

Responsible Party

Principal Investigator

Sandra Dumanski

Assistant Professor

University of Calgary

Eligibility Criteria

Inclusion Criteria

•female sex
•a diagnosis of chronic kidney disease or end stage kidney disease
•age 18-51

Exclusion Criteria

•Pregnancy, breastfeeding, current use of menopausal hormone therapy or gender affirming hormone therapy, or factors that would affect ovarian function, such as polycystic ovarian syndrome, premature ovarian insufficiency, ovarian malignancy, gonadotoxic chemotherapy, surgical oophorectomy, or previous radiation to the pelvis.