The Potential Role of Testosterone Between Hypertension and Target Organ Damage in Postmenopausal Hypertensive Women
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypertension
- Sponsor
- LanZhou University
- Enrollment
- 322
- Primary Endpoint
- Relative indexes of myocardial remodeling
- Last Updated
- 8 years ago
Overview
Brief Summary
The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence of hypertension. Therefore, the investigators hypothesize that testosterone has potential role between hypertension and target organ damage in postmenopausal hypertensive women. And the objective is to evaluate the effects of testosterone between hypertension and target organ damage in postmenopausal hypertensive women.
Investigators
Jing Yu
Principal Investigator
LanZhou University
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of hypertension
- •Women are all postmenopausal
- •Men are matched with women.
Exclusion Criteria
- •Secondary hypertension
- •Coronary disease
- •Heart failure
- •Arterial fibrillation
- •Previous myocardial infarction
- •Previous stroke
- •Malignant disease
- •Kidney failure
- •Liver failure
- •Neoplastic disease
Outcomes
Primary Outcomes
Relative indexes of myocardial remodeling
Time Frame: Baseline
Cardiac structure (left ventricular mass index in grams for square meter) measurement.
The level of testosterone (T)
Time Frame: Baseline
Blood samples used to analyze the levels of sexual hormones were collected between morning 8:00 and 9:00 after an overnight fast. Testosterone (T) units on nanogram per deciliter.
Ambulatory blood pressure monitoring
Time Frame: Baseline
Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment.