The Potential Role of Testosterone Between Hypertension and Target Organ Damage in Postmenopausal Hypertensive Women
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 322
- 主要终点
- Relative indexes of myocardial remodeling
研究概览
简要总结
The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence of hypertension. Therefore, the investigators hypothesize that testosterone has potential role between hypertension and target organ damage in postmenopausal hypertensive women. And the objective is to evaluate the effects of testosterone between hypertension and target organ damage in postmenopausal hypertensive women.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of hypertension
- •Women are all postmenopausal
- •Men are matched with women.
排除标准
- •Secondary hypertension
- •Coronary disease
- •Heart failure
- •Arterial fibrillation
- •Previous myocardial infarction
- •Previous stroke
- •Malignant disease
- •Kidney failure
- •Liver failure
- •Neoplastic disease
- •Severe neurological diseases
- •Severe metabolic or organic decompensation
- •Refuse to sign the informed consent form
结局指标
主要结局
Relative indexes of myocardial remodeling
时间窗: Baseline
Cardiac structure (left ventricular mass index in grams for square meter) measurement.
The level of testosterone (T)
时间窗: Baseline
Blood samples used to analyze the levels of sexual hormones were collected between morning 8:00 and 9:00 after an overnight fast. Testosterone (T) units on nanogram per deciliter.
Ambulatory blood pressure monitoring
时间窗: Baseline
Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment.
次要结局
未报告次要终点
研究者
Jing Yu
Principal Investigator
LanZhou University