Association Between the Prevalence of Cardiovascular Risk Factors and New Use of Testosterone

Completed

Brief Summary: We will investigate if testosterone is preferentially given to patients at higher risk of cardiovascular events. If this is the case, then observational studies may be prone to selection bias resulting in overestimation of the cardiovascular risk associated with testosterone when compared to a healthier population not taking testosterone

Recruitment & Eligibility

Inclusion Criteria

All male individuals in the source population with a first testosterone use during the study period will be included as cases. The date of the GP consultation associated with the first testosterone prescription will be designated as the index day.

Exclusion Criteria

Patients of less than 18 years on the index day, with less than 2-year contribution to the CPRD-HES link before the index day, or with use of testosterone before the study period will be excluded from the group of cases.

Arm && Interventions

Group	Intervention	Description
Case group: Testosterone Product	Testosterone Product	Male subjects prescribed testosterone in UK

Primary Outcome Measures

Name	Time	Method
Estimation of the association between cardiovascular risk factors and initiation of testosterone therapy	Retrospectively from 01 January 2001 to 31 March 2016

Secondary Outcome Measures

Name	Time	Method

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