The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- change in esophageal inflammation from baseline to 14 days
研究概览
简要总结
The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.
详细描述
Reflux esophagitis is thought to be caused by gastric acid that refluxes into the esophagus, causing injury. Newer data suggest that reflux of gastric juice into the esophagus stimulates HIF-2a, which increases production of inflammatory cytokines. These cytokines are thought to lead to reflux esophagitis. The investigators plan to study the relationship of HIF-2a to inflammatory cytokines in patients with known gastroesophageal reflux disease and reflux esophagitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •U.S Veteran
- •History of Los Angeles Grade C erosive esophagitis
排除标准
- •Inability to provide informed consent
- •Esophageal varices
- •Warfarin use
- •Coagulopathy that precludes safe biopsy of the esophagus
- •Comorbidity that precludes safe participation in the study
- •Allergy to fluorescein sodium
- •Pregnancy
结局指标
主要结局
change in esophageal inflammation from baseline to 14 days
时间窗: day 0 and day 14
inflammation of the squamous esophageal mucosa will be measured at baseline and at 14 days
次要结局
- change in HIF-2a levels from baseline to 14 days(day 0 and day 14)
研究者
Stuart Spechler
Professor of Medicine
Dallas VA Medical Center