The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
- Conditions
- Gastroesophageal Reflux DiseaseEsophagitisReflux Esophagitis
- Registration Number
- NCT01733810
- Lead Sponsor
- Dallas VA Medical Center
- Brief Summary
The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.
- Detailed Description
Reflux esophagitis is thought to be caused by gastric acid that refluxes into the esophagus, causing injury. Newer data suggest that reflux of gastric juice into the esophagus stimulates HIF-2a, which increases production of inflammatory cytokines. These cytokines are thought to lead to reflux esophagitis. The investigators plan to study the relationship of HIF-2a to inflammatory cytokines in patients with known gastroesophageal reflux disease and reflux esophagitis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
- U.S Veteran
- History of Los Angeles Grade C erosive esophagitis
- Inability to provide informed consent
- Esophageal varices
- Warfarin use
- Coagulopathy that precludes safe biopsy of the esophagus
- Comorbidity that precludes safe participation in the study
- Allergy to fluorescein sodium
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method change in esophageal inflammation from baseline to 14 days day 0 and day 14 inflammation of the squamous esophageal mucosa will be measured at baseline and at 14 days
- Secondary Outcome Measures
Name Time Method change in HIF-2a levels from baseline to 14 days day 0 and day 14 Amount of HIF-2a present will be measured at baseline and at 14 days
Trial Locations
- Locations (1)
Dallas VA Medical Center
🇺🇸Dallas, Texas, United States
Dallas VA Medical Center🇺🇸Dallas, Texas, United States