Sensitivity and Specificity of Leucocytes Subpopulation Versus Platelet Indices in Prediction of Clinical Outcome for Candidates With Sepsis. A Bi-centric Clinical Trial

Minia University0 sites161 target enrollmentSeptember 25, 2024

ConditionsSepsis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Sepsis
Sponsor: Minia University
Enrollment: 161
Primary Endpoint: Sensitivity of either leucocyte subpopulation, platelet indices with early clinical outcome
Status: Not yet recruiting
Last Updated: last year

Leucocyte subpopulation and platelet indices analysis can predict clinical outcome

Registry

clinicaltrials.gov

Start Date

September 25, 2024

End Date

August 20, 2025

Last Updated

last year

Study Type

Observational

Sex

All

Sponsor

Minia University

Responsible Party

Principal Investigator

Mina Maher

Ass professor anesthesia and pain

Minia University

•Adult population of both sex, aged 20 or older admitted to the ICU with a diagnosis of sepsis were screened for inclusion within 48 h of presentation to the hospital. Sepsis was defined as per the Sepsis-3 definition, 6 ie, the presence of suspected or documented infection with organ dysfunction determined by an acute increase of sequential organ failure assessment (SOFA) score by 2 or more points

•Patient refusal.
•History of surgery in the last 7 days from admission.
•Immunocompromised population ( post-transplantation, steroid use \> 5 mg per day, malignancy, HIV, on chemotherapy).
•Population with history of thrombocytopenia ( ITP, aplastic anemia, drug induced)
•History of thrombocytosis ( idiopathic thrombocytosis, post-splenectomy)
•History of platelet transfusion one week before admission.
•Bone marrow transplanted population .
•Chronic liver and kidney disease.
•Von-Willebrand disease.
•Patients on antiplatelet therapy ( Aspirin, clopidogrel).

Sensitivity of either leucocyte subpopulation, platelet indices with early clinical outcome

Time Frame: 1 week

Post hoc analysis .... \< 50 %= poor sensitivity..... \> 50%= strong sensitivity

Specificity of either leucocyte subpopulation, platelet indices with early clinical outcome

Time Frame: 1 week

Post hoc analysis .... \< 50 %= poor sensitivity..... \> 50%= strong sensitivity

correlation between leucocytes at enrollment , 7 days with ICU mortality(1 week)
correlation between platelet indices at enrollment , 7 days with ICU mortality(one week)
correlation between platelet indices at enrollment , 7 days with incidence of mechanical ventilation(1 week)
correlation between leucocytes at enrollment , 7 days with incidence of mechanical ventilation(1week)
correlation between leucocytes at enrollment , 7 days with incidence of acute kidney injury(1 week)
correlation between platelet indices at enrollment , 7 days with incidence of acute kidney injury(1 week)