Appetite Regulation and Mycoprotein
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 2
- 主要终点
- Energy intake at ad-libitum meal
研究概览
简要总结
The purpose of this study is to investigate the effect of eating various levels of mycoprotein (Quorn) on feelings of appetite, energy intake and levels of gut hormones in overweight volunteers.
详细描述
Owing to its relatively high protein and fibre content, mycoprotein presents an attractive food product to improve appetite regulation and postprandial glycaemic and insulin responses in overweight and obese individuals at risk of developing T2DM
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and females between the ages of 18 and 65
- •body mass index (BMI) 25-32kg/m2
- •Weight stable over the past 6 months
- •No known major illness or eating disorder nor on any medication that may impact on appetite or hormone levels.
- •No paracetamol or other analgesic in the previous 48 hours
- •A score of <2.5 in the Dutch Eating Behaviour Questionnaire (DEBQ)
- •A score of <2 in the SCOFF questionnaire
排除标准
- •Persons outside the age and BMI ranges stated above
- •Pregnant and lactating women
- •Weight variation of greater than 5% in the last 6 months
- •Any diagnosed major illness
- •Any paracetamol or analgesic intake in the last 48 hours
- •Diagnosed eating disorder
- •Allergy to mycoprotein or mushrooms
- •Regular consumption of Quorn products
- •Dislike of any of the test foods or drinks
- •A score of >2.5 in the Dutch Eating Behaviour questionnaire
- •A score of 2 or more in the SCOFF questionaire
研究组 & 干预措施
mycoprotein
3 levels of mycoprotein will be consumed
干预措施: mycoprotein (Dietary Supplement)
control protein
3 levels of a control protein will be consumed
干预措施: control protein (Dietary Supplement)
结局指标
主要结局
Energy intake at ad-libitum meal
时间窗: upon completion of all participants, expected timeframe: 2 years
Energy intake will be assessed during an ad-libitum meal at 180 minutes at the end of each study visit. Participants will be offered a meal in excess and asked to eat until they feel comfortably full. The meal will be weighed before and after consumption and energy intake will be calculated from the manufacturer's reported nutritional composition.
次要结局
- Glucagon-like peptide-1 (GLP-1)(upon completion of all participants, expected at 2 years)
- peptide tyrosine-tyrosine (PYY) levels(upon completion of all participants, expected at 2 years)