Prescribing the maximum tolerated dose of walking for people with severe knee osteoarthritis: A Phase II, Randomised Controlled Trial

Not Applicable

Completed

• Conditions: Osteoarthritis of the knee; Cardiovascular disease; Musculoskeletal - Osteoarthritis; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12615000015549
• Lead Sponsor: Jason Wallis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-01-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

(1) Adult aged at least 50 years and living independently in the community.
(2) Diagnosed with severe knee osteoarthritis rated as grade III or IV determined radiogaphically.
(3) Have a cardiovascular risk profile with at least 2 total risk factors using stage 2 of the Adult Exercise Screening Tool.
(4) Able to participate safely in the moderate-intensity physical activity trial using stage 1 of the Adult Exercise Screening Tool.
(5) Able to understand English.

Exclusion Criteria

(1) Live in supported accommodation such as a nursing home.
(2) Report daily resting level of pain to be 9 or 10 on a 0 (no pain) to 10 (worst possible pain) Numerical Pain Rating Scale.
(3) Have very high levels of psychological distress as measured by the Kessler 10 questionnaire with a K10 score > 29.
(4) Have an intellectual impairment as measured by the Short Portable Mental Status Questionnaire with a score of 7 or less.
(5) Have a systemic arthritic condition such as rheumatoid arthritis.
(6) Have a neurological condition that affects walking.
(7) Had knee surgery or intra-articular corticosteroid injection within past six months.
(8) Using oral corticosteroids within four weeks.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome is average knee pain over the previous week measured by a 0-10 Numerical Pain Rating Scale. [Baseline and post intervention (Week 12)]