Comparison of symptoms of knee joint pain with its structural and functional changes

Not yet recruiting

Conditions: Osteoarthritis of knee, unspecified,

Registration Number: CTRI/2020/03/024358

Lead Sponsor: Dr Varsha Sadhale

Brief Summary: Prevalence of joint diseases is increasing in the society due to sedentary life style , stress and strain in day today life. Osteoarthritis is the second most common joint disease with an incidence rate of 22 percent to 39 percent in India. It is more common in women than men, increases dramatically with age, the prognosis worsens and finally the person ends up with joint replacement. Such chronic patients mainly approach Ayurveda to receive treatment so as to avoid the surgical interventions and to improve quality of life. Structural as well functional aspects of joints should be explored to understand the patho-physiology of joint diseases so as to decide the treatment plan. The anatomy of joint is not much explored in *Ayurveda Shareer*. There are mainly two types of joints i.e. *cheshtavant (*movable) and *sthira* (immovable) joints mentioned in classical textsFurther classification of joints enumerates eight types of *sandhi.*The eight types are namely *kora, ulukhala ,samudga, pratara ,tunnasevani, vayastund, mandal,* and *shankhavart.* The presence of *Shleshmadhara kala* and *shleshak kapha* at all the *sandhi* is enumerated by Sushrutacharya..This *kala* along with *Shleshak kapha* helps in smooth functioning of all joints . *Kala* are explained as limiting membranes between *dhatu* and *ashay* which is formed in intra-uterine life*. Kleda* between *dhatu* and *Ashay* becomes *pakva* and gets transformed into mucoid , tendinous and membranous structure which is known as *kala..*From the previous available studies it is proved that *Shleshmadhara kala* can be compared with synovial membrane and *shleshak kapha* with the synovial fluid.But this *shareer* about *sandhi* and *kala* explained in Ayurveda Texts is not applied in clinical practice. In various joint diseases the structural and functional changes are observed in relation to joints which affects the further prognosis of disease. In this study patients of *sandhigata vata* are examined to observe such changes at various stages. *Sandhigata vata* mentioned by Charakacharya in *chikitsasthan* 28th chapter and Madhavnidan can be compared with osteoarthritis as per available literature.Understanding the pathogenesis of osteoarthritis is very important for deciding treatment plan, monitoring treatment efficacy and predicting disease outcome. Ayurvedaâ€™s approach varies from that of modern science in diagnosis of disease. *Anuman Praman* is mainly used in Ayurveda i.e. Symptomatology based on vitiation of *dosha* helps in accurate diagnosis of disease condition. But in modern science main emphasis is given on *Pratyaksha pramana.* MRI, Radiograph, Ultra sonography, Histopathological studies are used mainly to detect the structural changes in Osteoarthritis which is characterized by degenerative changes in the bones, cartilage, menisci, ligaments, and synovial tissue. Hence in this study pre diagnosed patients of *sandhigata vata* (osteoarthritis) having symptoms such as *sandhishula* (pain), *sandhi shoth* (inflammation), *Aatop* (crepitus), and *Sandhigraha* (stiffness) will be selected and an attempt will be made to understand the structural changes observed in knee joint osteoarthritis with special emphasis on *shleshmadhara kala* along with the functional changes based on range of motion and correlation of this will be established with the symptoms *.*

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 310

Inclusion Criteria

OPD and IPD prediagnosed patients of sandhigata vata.

Exclusion Criteria

Patients non willing .
patients having any other serious illness.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Positive corelation of Ayurvedic and Modern methods of diagnosis of Knee osteoarthritis	2 Years

Secondary Outcome Measures

Name	Time	Method
development of score based scale to know the stage of sandhigata vata.	two years

Trial Locations

Locations (1): Arogyashala Rugnalay Nashik
🇮🇳
Nashik, MAHARASHTRA, India
Arogyashala Rugnalay Nashik
🇮🇳Nashik, MAHARASHTRA, India
Dr Varsha Sadhale
Principal investigator
9822173345
shravanigirishkulkarni@gmail.com