Systemic Inflammatory Indices as a Non-invasive Grading Modality for Endometriosis

Completed

• Conditions: Endometriosis
• Interventions: Procedure: Diagnostic laparoscopy; Diagnostic Test: Full Blood Count (FBC)

• Registration Number: NCT06298617
• Lead Sponsor: Benha University

Brief Summary

Endometriosis (EMs) is one of the commonest chronic inflammatory disorder affecting women and is characterized by the presence and growth of endometrial-like glandular epithelial and stromal cells outside the uterus leading to multiple clinical symptoms affecting patients quality of life and fertility with high recurrence rate . The systemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) are documented as prognostic serum biomarker in many kinds of cancer and for the need and outcomes of adjuvant therapies for various cancers .

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-01
• Primary Completion: 2023-07-30
• Study Completion: 2023-12-25
• Status Verified: 2024-03
• Study First Submitted: 2024-03-01
• Study First Submitted QC: 2024-03-01
• Study First Posted: 2024-03-07
• Last Update Submitted: 2024-03-09
• Last Update Posted: 2024-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 88

Inclusion Criteria

• Women with clinical manifestations suggestive of having EM;
• Women who was professionally diagnosed;
• Women who was diagnosed by radiologic workup;
• Women were free of exclusion criteria.

Exclusion Criteria

• Women with EM and were maintained on treatment or underwent operative interference during the last three months;
• Patients had autoimmune diseases, maintained on immunosuppressive therapy for any indication;
• Women with cancer elsewhere in the body or receiving adjuvant therapies for cancer;
• Patients receiving therapies for viral disorders especially COVID;
• Patients refusing to undergo the exploratory laparoscopy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study group	Diagnostic laparoscopy	-
Study group	Full Blood Count (FBC)	-

Primary Outcome Measures

Name	Time	Method
Indices' ability to predict EM stage	8 months	Number of patients was diagnosed with EM and got staged right through a calculated indices to the patients who went for exploratory laparoscopy which improve the chances of calculated indices facing the laparoscopy.

Trial Locations

Locations (1)

Benha University; 🇪🇬 Banhā, Al Qalyobia, Egypt