Evaluation of the Cone Outer Segment Tips Line After Epiretinal Membrane Surgery

Not Applicable

Completed

• Conditions: Epiretinal Membrane
• Interventions: Device: optical coherence tomography

• Registration Number: NCT01549249
• Lead Sponsor: Kyorin University

Brief Summary

The recovery of the cone outer segment tips (COST) line after epiretinal membrane (ERM) surgery using spectral-domain optical coherence tomography (SD-OCT) was assessed.

Detailed Description

Epiretinal membrane (ERM) may cause decreased central vision or metamorphopsia. Pars plana vitrectomy with membrane peeling has become the standard treatment for epiretinal membrane. However, visual recovery or symptomatic relief is not always satisfactory in all eyes despite successful membrane removal. Spectral domain optical coherence tomography (SD-OCT) is a non-invasive imaging device for various vitreoretinal diseases. Cone outer segment tips (COST) line is a line observed between IS/OS line and RPE in SD-OCT. The investigators examined the correlation of visual acuity and the recovery of photoreceptor layer after ERM surgery, taking COST line into account as a new parameter

Study Timeline

• Study Start: 2008-06
• Primary Completion: 2010-11
• Study Completion: 2011-11
• Study First Submitted: 2012-03-06
• Study First Submitted QC: 2012-03-08
• Study First Posted: 2012-03-09
• Status Verified: 2012-11
• Last Update Submitted: 2012-11-12
• Last Update Posted: 2012-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 333

Inclusion Criteria

• Patients who received epiretinal membrane surgery between June, 2008, and November, 2010, at Kyorin Eye Center.
• Only eyes with postoperative follow-up period more than 6 months were included.

Exclusion Criteria

• Eyes with secondary epiretinal membrane (previous history of uveitis, intraocular surgery, pre-operatively noted retinal breaks, etc.) were excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
vitrectomy	optical coherence tomography	-

Primary Outcome Measures

Name	Time	Method
best-corrected visual acuity	one year

Secondary Outcome Measures

Name	Time	Method
Integrity and defect length of the photoreceptor layer detected by spectral-domain optical coherence tomography	one year

Trial Locations

Locations (1)

Kyorin Eye Center; 🇯🇵 Mitaka, Tokyo, Japan