Hypothyroidism in children with Hb E/Beta-thalassemia who received regular transfusion vs. those who underwent hematopoietic stem cell transplantatio

Recruiting

• Conditions: -Hypothyroidism in Hb E/Beta-thalassemia children who received regular transfusion -Hypothyroidism in Hb E/Beta-thalassemia children who underwent hematopoietic stem cell transplantation; Hypothyroidism; Hb E/Beta-thalassemia; HSCT; Transfusion-dependent; Children

• Registration Number: TCTR20210906001
• Lead Sponsor: none

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-06
• Study Completion: 2021-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Hb E/Beta-thalassemia patients who received regular blood transfusion for >1 year before enrollment in the study
2. Hb E/Beta-thalassemia patients who underwent allogeneic HSCT from October, 2003 to March, 2019 and were followed up >1 year before enrollment in the study and recovered completely without transfusion dependence

Exclusion Criteria

1.Patients who had abnormal TFT before diagnosis with severe Hb E/Beta-thalassemia
2.Patients who had thyroid function test done less than twice during treatment
3.Patients who were treated with HSCT more than one time

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hypothyroidism in Hb E/Beta-thalassemia patients who received regular transfusion more than 1 year after patients receiving regular transfusion Thyroid function test

Secondary Outcome Measures

Name	Time	Method
Hypothyroidism in Hb E/Beta-thalassemia patients who underwent HSCT more than 1 year after patients underwent HSCT Thyroid function test