Efficacy and safety of conservative versus liberal fluid therapy in critically ill patients with cirrhosis admitted to the intensive care unit

Professor Rinaldo Bellomo0 个研究点目标入组 40 人开始时间: 2015年4月23日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•1.Adults (>18 years) admitted to ICU with decompensated cirrhosis
•2.Hypotension (Mean Arterial Pressure (MAP) <65mmHg)
•3.Clinical need for of a Central Venous Catheter (CVC) and arterial line (capable of cardiac output measurement (e.g. PiCCO or FloTrac)

•*Fulminant Hepatic Failure
•*Oliguria requiring frusemide administration via a continuous infusion prior to or immediately on admission to ICU
•*Renal failure requiring renal replacement therapy prior to or immediately on admission to ICU
•*Diagnosis of Acute Respiratory Distress Syndrome (ARDS)
•New, bilateral pulmonary infiltrates evident on chest X-Ray
•Absence of clinical evidence for, or measured findings of left atrial hypertension
•PaO2:FiO2 ratio of <200
•*Severe pre-existing cardiopulmonary disease, e.g.;
•NYHA class III or IV heart failure
•Pulmonary hypertension
•*Admission to ICU for severe bleeding (e.g. oesophageal varices complicated by haemorrhage)
•*Requirement for total parenteral nutrition (TPN)

发起方

Professor Rinaldo Bellomo