Risk Factors for Exertional Heat Illness
Active, not recruiting
- Conditions
- Exertional Heat Illness
- Registration Number
- NCT04979455
- Lead Sponsor
- Liverpool John Moores University
- Brief Summary
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat. These conditions reduce operational effectiveness and expose personnel to a risk of incapacitation and death from exertional heat illness (EHI).
The aim of this study is to examine traditional and novel risk factors that may increase thermal strain and EHI likelihood in military recruits undergoing strenuous physical exercise.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 783
Inclusion Criteria
- Men and women aged 17-35 years enrolled in military training
Exclusion Criteria
- Self-report as pregnant
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sleep quality, measured by actigraphy, between EHI and control group Throughout study - up to 1 week Circulating C-Reactive Protein in EHI and control group Baseline Circulating Aspartate Aminotransferase in EHI and control group Baseline Circulating Claudin 3 in EHI and control group Baseline Gastrointestinal illness symptomology, measured by gastrointestinal symptoms questionnaire, in EHI and control group Throughout study - up to 1 week 0-10 Scale per symptom. Higher score indicates worse outcome
Urine osmolality in EHI and control group Baseline Circulating Creatine kinase in EHI and control group Baseline Circulating Lipopolysaccharide binding protein in EHI and control group Baseline Salivary cortisol in EHI and control group Throughout study - up to 1 week Abundance and diversity of gastrointestinal microbiota in EHI and control group Baseline Core temperature in EHI and control group 1 Day Sleep quantity, measured by actigraphy, between EHI and control group Throughout study - up to 1 week Circulating Interleukin 6 in EHI and control group Baseline Detection of infectious pathogens in EHI and control groups Throughout study - up to 1 week Respiratory illness symptomology, measured by Jackson common cold questionnaire, in EHI and control group Throughout study - up to 1 week 0-24 Scale. Higher score indicates worse outcome
Fitness in EHI and control group - participants ranked by time to complete fitness test Baseline Circulating Zonulin in EHI and control group Baseline Circulating immunoglobulin E in EHI and control group Baseline Sleep quality and quantity, measured by Pittsburgh Sleep Quality Index, in EHI and control group Throughout study - up to 1 week 0-21 Scale. Higher score indicates worse outcome
Circulating Alanine Aminotransferase in EHI and control group Baseline Heart rate in EHI and control group 2 Hours Body mass index in EHI and control group Baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Commando Training Centre Royal Marine
🇬🇧Lympstone, Devon, United Kingdom
Commando Training Centre Royal Marine🇬🇧Lympstone, Devon, United Kingdom