Prospective Investigation of Risk Factors for Exertional Heat Illness
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 783
- 试验地点
- 1
- 主要终点
- Heart rate in EHI and control group
研究概览
简要总结
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat. These conditions reduce operational effectiveness and expose personnel to a risk of incapacitation and death from exertional heat illness (EHI).
The aim of this study is to examine traditional and novel risk factors that may increase thermal strain and EHI likelihood in military recruits undergoing strenuous physical exercise.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 17 Years 至 35 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women aged 17-35 years enrolled in military training
排除标准
- •Self-report as pregnant
结局指标
主要结局
Heart rate in EHI and control group
时间窗: 2 Hours
Sleep quality, measured by actigraphy, between EHI and control group
时间窗: Throughout study - up to 1 week
Circulating C-Reactive Protein in EHI and control group
时间窗: Baseline
Circulating Aspartate Aminotransferase in EHI and control group
时间窗: Baseline
Circulating Claudin 3 in EHI and control group
时间窗: Baseline
Gastrointestinal illness symptomology, measured by gastrointestinal symptoms questionnaire, in EHI and control group
时间窗: Throughout study - up to 1 week
0-10 Scale per symptom. Higher score indicates worse outcome
Urine osmolality in EHI and control group
时间窗: Baseline
Circulating Creatine kinase in EHI and control group
时间窗: Baseline
Circulating Lipopolysaccharide binding protein in EHI and control group
时间窗: Baseline
Salivary cortisol in EHI and control group
时间窗: Throughout study - up to 1 week
Abundance and diversity of gastrointestinal microbiota in EHI and control group
时间窗: Baseline
Core temperature in EHI and control group
时间窗: 1 Day
Sleep quantity, measured by actigraphy, between EHI and control group
时间窗: Throughout study - up to 1 week
Circulating Interleukin 6 in EHI and control group
时间窗: Baseline
Detection of infectious pathogens in EHI and control groups
时间窗: Throughout study - up to 1 week
Respiratory illness symptomology, measured by Jackson common cold questionnaire, in EHI and control group
时间窗: Throughout study - up to 1 week
0-24 Scale. Higher score indicates worse outcome
Body mass index in EHI and control group
时间窗: Baseline
Fitness in EHI and control group - participants ranked by time to complete fitness test
时间窗: Baseline
Circulating Zonulin in EHI and control group
时间窗: Baseline
Circulating immunoglobulin E in EHI and control group
时间窗: Baseline
Sleep quality and quantity, measured by Pittsburgh Sleep Quality Index, in EHI and control group
时间窗: Throughout study - up to 1 week
0-21 Scale. Higher score indicates worse outcome
Circulating Alanine Aminotransferase in EHI and control group
时间窗: Baseline
次要结局
未报告次要终点