Prospective Investigation of Risk Factors for Exertional Heat Illness
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Exertional Heat Illness
- Sponsor
- Liverpool John Moores University
- Enrollment
- 783
- Locations
- 1
- Primary Endpoint
- Heart rate in EHI and control group
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat. These conditions reduce operational effectiveness and expose personnel to a risk of incapacitation and death from exertional heat illness (EHI).
The aim of this study is to examine traditional and novel risk factors that may increase thermal strain and EHI likelihood in military recruits undergoing strenuous physical exercise.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Men and women aged 17-35 years enrolled in military training
Exclusion Criteria
- •Self-report as pregnant
Outcomes
Primary Outcomes
Heart rate in EHI and control group
Time Frame: 2 Hours
Sleep quality, measured by actigraphy, between EHI and control group
Time Frame: Throughout study - up to 1 week
Circulating C-Reactive Protein in EHI and control group
Time Frame: Baseline
Circulating Aspartate Aminotransferase in EHI and control group
Time Frame: Baseline
Circulating Claudin 3 in EHI and control group
Time Frame: Baseline
Gastrointestinal illness symptomology, measured by gastrointestinal symptoms questionnaire, in EHI and control group
Time Frame: Throughout study - up to 1 week
0-10 Scale per symptom. Higher score indicates worse outcome
Urine osmolality in EHI and control group
Time Frame: Baseline
Circulating Creatine kinase in EHI and control group
Time Frame: Baseline
Circulating Lipopolysaccharide binding protein in EHI and control group
Time Frame: Baseline
Salivary cortisol in EHI and control group
Time Frame: Throughout study - up to 1 week
Abundance and diversity of gastrointestinal microbiota in EHI and control group
Time Frame: Baseline
Core temperature in EHI and control group
Time Frame: 1 Day
Sleep quantity, measured by actigraphy, between EHI and control group
Time Frame: Throughout study - up to 1 week
Circulating Interleukin 6 in EHI and control group
Time Frame: Baseline
Detection of infectious pathogens in EHI and control groups
Time Frame: Throughout study - up to 1 week
Respiratory illness symptomology, measured by Jackson common cold questionnaire, in EHI and control group
Time Frame: Throughout study - up to 1 week
0-24 Scale. Higher score indicates worse outcome
Body mass index in EHI and control group
Time Frame: Baseline
Fitness in EHI and control group - participants ranked by time to complete fitness test
Time Frame: Baseline
Circulating Zonulin in EHI and control group
Time Frame: Baseline
Circulating immunoglobulin E in EHI and control group
Time Frame: Baseline
Sleep quality and quantity, measured by Pittsburgh Sleep Quality Index, in EHI and control group
Time Frame: Throughout study - up to 1 week
0-21 Scale. Higher score indicates worse outcome
Circulating Alanine Aminotransferase in EHI and control group
Time Frame: Baseline