Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation

Recruiting

• Conditions: Atrial Fibrillation (AF)

• Registration Number: NCT06951100
• Lead Sponsor: University of Edinburgh

Brief Summary

The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF)

The main questions this study aims to answer are:

1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease)

2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia

To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-04
• Study Start: 2025-04
• Study First Submitted: 2025-04-28
• Study First Submitted QC: 2025-04-28
• Last Update Submitted: 2025-04-28
• Study First Posted: 2025-04-30
• Last Update Posted: 2025-04-30
• Primary Completion: 2026-09
• Study Completion: 2029-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

1. Age 18 years and over
2. Primary presentation with symptoms related to atrial fibrillation
3. Atrial fibrillation with a ventricular rate >100 bpm on a 12-lead electrocardiogram
4. Able to provide informed consent

Exclusion Criteria

1. Previous myocardial infarction
2. Previous coronary revascularisation procedure
3. Patients in renal failure (eGFR <30ml/min/1.73m2) or major allergy to contrast media
4. Pregnancy or breast feeding
5. Deemed unsuitable for participation in the study by the attending clinician
6. Previous enrolment in the trial

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of obstructive coronary artery disease	within 4 weeks of presentation	Presence of obstructive coronary artery disease as defined as at least one stenosis ≥70% in a major epicardial coronary artery or ≥50% in the left main stem on CTCA or invasive coronary angiography

Secondary Outcome Measures

Name	Time	Method
Imaging evidence of new myocardial infarction	within 4 weeks of presentation	Imaging evidence of new myocardial infarction

Trial Locations

Locations (1)

Royal Infirmary of Edinburgh; 🇬🇧 Edinburgh, East of England, United Kingdom