Study of the Effects of Glutamine on Glycemia, Glucagon-like Peptide-1 (GLP-1) and Insulin Secretion in Man
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Postprandial Glucose Area Under the Curve (AUC)
研究概览
简要总结
This study investigated the effect of glutamine, an amino acid, glycemia, glucagon-like peptide-1 (GLP-1) and insulin in participants with type 2 diabetes.
详细描述
In this study, we investigated the effect of glutamine, an amino acid, on glycemia and on GLP-1 and insulin in participants with type 2 diabetes. Preliminary data published by our group suggests that glutamine is a strong determinant of GLP-1 secretion in vitro. We tested the hypothesis that glutamine lowers postprandial blood glucose and investigated whether the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin modifies this effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes, on metformin or diet alone (not sulphonylureas or insulin)
排除标准
- •Malabsorption, renal or liver disease, treatment with steroids
研究组 & 干预措施
Glutamine+Sitagliptin
Glutamine 30 g/d (15 g with breakfast and dinner) + Sitagliptin
干预措施: Sitagliptin (Drug)
Glutamine+Placebo
Glutamine 30 g/d (15 g with breakfast and dinner) + placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Postprandial Glucose Area Under the Curve (AUC)
时间窗: 0 to 180 minutes
The area under the curve (AUC) of the postprandial glucose following a meal challenge
次要结局
- Fructosamine(4 weeks)
研究者
Dr Jerry Greenfield
Prof
Garvan Institute of Medical Research