Biomarker Discovery in Lung Cancer - Malaysia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- To discover and validate RNA and methylated cell-free DNA cancer biomarkers that can discriminate between high-risk and lung cancer patients.
研究概览
简要总结
This study aims to
- Identify biomarkers and signatures to differentiate between high-risk and lung cancer patients.
- Discover blood-based biomarkers that can be used as an adjunct test to imaging diagnosis to improve patient follow-up.
详细描述
With existing evidence showing the utility of using liquid biopsy for early cancer detection, the investigators hypothesized that cell-free DNA and/or RNA expression changes during disease progression, and biomarker signature can be derived from the changes in expression levels. The investigators aim to discover and validate RNA and methylated cell-free DNA cancer biomarkers that can discriminate between high-risk and lung cancer patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female subjects aged 30 and above.
- •No previous history of any cancers.
- •Able to provide X-ray and/or LDCT results.
- •Have either COPD or pulmonary nodules measuring less than 11mm, or deemed not for biopsy by attending physician
- •Willing to go back for a follow-up X-ray or LDCT scan in the next clinical follow up as per standard of care.
- •Willing to provide up to 30mL of blood in month-0 (first visit) and up to 21mL in the next standard of care follow up visit (second visit).
排除标准
- •Subject has received chemotherapy or radiotherapy for cancer treatment, and any other cancer-related treatment.
- •Subject is pregnant or lactating (self-declaration).
- •Subject is unwilling or unable to provide signed informed consent
结局指标
主要结局
To discover and validate RNA and methylated cell-free DNA cancer biomarkers that can discriminate between high-risk and lung cancer patients.
时间窗: 3 years
To discover and validate RNA and methylated cell-free DNA cancer biomarkers that can discriminate between high-risk and lung cancer patients.
次要结局
未报告次要终点
研究者
Poh Mau Ern
Associate Professor Dr Poh Mau Ern
University of Malaya