Effect of Nicorandil on contrast-induced nephropathy

Phase 3

Recruiting

Conditions: contrast-induced nephropathy.
Nephropathy induced by other drugs, medicaments and biological substances
ICD 10- N1

Registration Number: IRCT20230110057096N1

Lead Sponsor: Rasht University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 264

Inclusion Criteria

Patients with GFR<60 ml/min that do not undergo dialysis
Patients who are a candidate for non-emergent CAG or non-primary PCI and have 24-hour time for treatment with Nicorandil

Exclusion Criteria

Consuming Metformin, ACEI, ARB, Nicorandil, Nitrocontin, Sildenafil and other phosphodiesterase 5 inhibitors in the last 24 hours
having urinary tract infection(UTI)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Creatinine level. Timepoint: Measuring level of creatinine on the days 0-3-5. Method of measurement: Creatinine measurement will be done with the help of a quantitative detection kit for creatinine in serum, plasma or urine with the photometric method of Pars Azmoun company and with the callimetric method without removing proteins based on the JAFFE method.;BUN level. Timepoint: Measuring level of BUN on the days 0-3-5. Method of measurement: BUN will be measured with the help of Urea UV quantitative detection kit in serum, plasma and urine with the photometric method of Pars Azmoun company and with the enzyme method based on the Urease-GLDH method.;Urinary output. Timepoint: Measuring urinary output on the days 0-3-5. Method of measurement: The amount of urinary output is calculated by measuring the volume of a person's urine.

Secondary Outcome Measures