Comparative Study of Magnesium Sulphate Vs Dexmedetomidine as Adjuvants to Bupivacaine in Scalp Nerve Block: Effects on Intraoperative Hemodynamic Parameters and Postoperative Pain for Patients Undergoing Supratentorial Brain Tumour Craniotomy (A Prospective Randomized Comparative Study)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 177
- 试验地点
- 1
- 主要终点
- 1. To evaluate and compare intraoperative hemodynamic parameters, including heart rate (HR), systolic blood pressure, diastolic blood pressure, and mean arterial pressure.
研究概览
简要总结
This study compares Magnesium Sulphate vs. Dexmedetomidine as adjuvants to Bupivacaine in scalp nerve block for patients undergoing supratentorial brain tumor craniotomy. It evaluates intraoperative hemodynamic stability, postoperative pain relief, and opioid consumption. 177 patients are randomized into three groups receiving Bupivacaine alone, with Dexmedetomidine, or with Magnesium Sulphate. Hemodynamic parameters, pain scores (VAS), cortisol levels, and analgesic requirements are assessed. The goal is to determine which adjuvant optimizes pain control and recovery while reducing opioid use. The study aims to improve anesthesia strategies and postoperative outcomes for brain surgery patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient fulfilling criteria ASA Classes I/ II
- •Patient aged 18-65 years of both sexes.
- •Patients undergoing elective supratentorial craniotomy under general anaesthesia.
排除标准
- •Patient with ASA CLASS III, IV & V Refusal of patient Patient with difficult surgical anatomy Patient with previous craniotomy incision Local infection at the site of injection History of allergy to opioid or local anaesthesia Inability to comprehend or participate in pain scoring system.
结局指标
主要结局
1. To evaluate and compare intraoperative hemodynamic parameters, including heart rate (HR), systolic blood pressure, diastolic blood pressure, and mean arterial pressure.
时间窗: intraoperatively | postoperatively
2. To measure and compare postoperative Visual Analogue Scale (VAS) scores.
时间窗: intraoperatively | postoperatively
3. To determine the time until the first request for rescue analgesia
时间窗: intraoperatively | postoperatively
次要结局
- • To observe and compare the need for supplemental analgesics during surgery.(• To analyze and compare serum cortisol levels.)
研究者
Swati Gupta
Mahatma Gandhi Medical College & Hospital