NL-OMON37742尚未招募不适用
The effects of plant stanol esters on intestinal mucosal gene expression profiles and microbiota composition in healthy human subjects. - Plant stanols and gene expression profile
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •aged between 18 and 60 years
- •Body Mass Index (BMI) between 20-30 kg/m2
- •mean serum total cholesterol < 7.8 mmol/L
排除标准
- •unstable body weight (weight gain or loss > 3 kg in the past two months) - active cardiovascular diseases like congestive heart failure or recent (<6 months) event (acute myocardial infarction, cerebral vascular incident) - severe medical conditions that might interfere with the study such as epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel disease and rheumatoid arthritis) - indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus - use of medication such as corticosteroids, diuretics or lipid lowering therapy - abuse of drug or alcohol (>21 units per week) - not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in sterol or stanol esters - use of an investigational product within another biomedical study within the previous month - pregnant or breast-feeding women - not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study and during the study - current smoker - anemia. with a Hb-level below 7.5 mmol/L for men and below 7.0 mmol/L for women, as indicated by the blood bank of Maastricht - gastrointestinal diseases - not willing to stop the consumption of probiotica and antibiotica during the study
研究者
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