Perioperative versus Postoperative Oral Calcium and Vitamin D Supplement to Prevent Symptomatic Hypocalcemia after Total Thyroidectomy: A Randomized Controlled Trial
Phase 1
Completed
- Conditions
- Patients who underwent total or completion thyroidectomy from June 1st, 2017 to June 30th, 2020 at the department of otolaryngology, Maharaj Nakorn Chiang Mai HospitalThyroidectomy, Hypocalcemia, Calcium, Vitamin D
- Registration Number
- TCTR20200622005
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
Patients who underwent total or completion thyroidectomy
Exclusion Criteria
1. Patients who have parathyroid diseases of hypoparathyroidism preoperatively
2. Abnormal serum calcium (normal range 8.5-10.2 mg/dl)
3. Abnormal serum phosphate (normal range 2.5-4.5 mg/dl)
4. Abnormal serum magnesium (normal range 1.32-2.14 mEq/L)
5. Abnormal creatinine clearance >60 ml/min
6. Abnormal liver function (Total bilirubin >1.5 mg/dl, AST >40 U/L, ALT >41 U/L, alkaline phosphatase >129 U/L)
7. Patients with underlying heart diseases
8. Patients who currently breast feeding or pregnancy
9. Patients who have calcium or vitamin D as current medications
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method symptoms of numbness, Trousseau's sign, Chvostek's sign 1st, 2nd, 3rd, and 14 days after the operation positive/negative symptoms of numbness, positive/negative Trousseau's sign, positive/negativeChvoste
- Secondary Outcome Measures
Name Time Method serum calcium level 1st, 2nd, 3rd, and 14 days after the operation serum calcium (mg/dl)