A Randomized control trial comparing three different group of drugs which can better decrease stress response to putting a tube in patients trachea for proper lung ventilation during general anaesthesia in laparoscopic surgery.
- Conditions
- Calculus of gallbladder without cholecystitis,
- Registration Number
- CTRI/2024/02/062361
- Lead Sponsor
- SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTER
- Brief Summary
This study is to compare between intravenous Magnesium Sulphate, Dexmedetomidine and Labetalol for attenuation of cardiovascular stress response during laryngoscope and endotracheal intubation in laparoscopic surgeries by monitoring change in heart rate and blood pressure. A total of 120 patients of ASA status 1 and 2 aged 18-60 years of age, of either sex undergoing elective laparoscopic surgeries under general anaesthesia requiring endotracheal intubation will be selected and then divided into 4 groups of 30 each. 1st group will be given Magnesium sulphate, 2nd group Dexmedetomidine , 3rd group Labetalol and 4th group 10 ml Normal saline to act as control. The attenuation of cardiovascular stress response will be compared among different groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 120
- 1)American society of anaesthesiologist grade 1 and 2 patients.
- 2)Patients undergoing elective laparoscopic surgeries.
- 1)patients refusal 2)Heart rate<60/min 3)systolic blood pressure of <100mmhg 4)Mallampatti grading 3 and 4 5) anticipated difficult intubation.
- 6)patients with systemic disorders like Left ventricular failure,any degree of heart block,ischemic heart disease,aortic stenosis and bronchial asthama.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To monitor change in heart rate during laryngoscopy and endotracheal intubation,and which drug is the best in blunting hemodynamic stress response during endotracheal intubation. T0:Base line HR,BP,Spo2 | T1:After induction | T2:Before laryngoscopy | T3:Immediately after laryngoscopy and intubation | T4:2 mins after intubation | T5:5mins after intubation | T6:Before pneumoperitoneum | T7:2mins after pneumoperitoneum | T8:5mins after pneumoperitoneum | T9:10mins after pneumoperitoneum | T10 :Before intubation | T11:Immediately after extubation. | T12:5mins after extubation.
- Secondary Outcome Measures
Name Time Method 1)To monitor change in blood pressure during laryngoscopy and intubation. 2)Requirement of analgesic supplementation intraoperatively.
Trial Locations
- Locations (1)
SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTER
🇮🇳Kancheepuram, TAMIL NADU, India
SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTER🇮🇳Kancheepuram, TAMIL NADU, IndiaDrkKarthikPrincipal investigator9884360796Karthikkrishnamoorthy1981@gmail.com