Role of dexmedetomidine and magnesium sulphate in controlling the stress response of intubation in patients undergoing operation.

Not yet recruiting

• Conditions: Measurement and Monitoring,

• Registration Number: CTRI/2021/06/034217
• Lead Sponsor: Yangchen Bhutia

Brief Summary

This study is a randomized,  parallel group,  placebo controlled double blinded trial to evaluate and compare the stress response attenuation between dexmedetomidine and magnesium sulphate in patients undergoing laryngoscopy and intubation. The study will be conducted in Department of Anaesthesiology, Regional institute of medical sciences, Imphal, Manipur, India. A total of 90 patients aged 18-60 years of either sex, ASA grade I and II will be randomly divided into three groups of 30 each and will be administered with the study drugs intravenously. Group D will receive Injection dexmedetomidine 0.5ug/kg diluted to 10ml normal saline, Group M will receive magnesium sulphate 20mg/kg diluted to 10ml normal saline and Group S will receive 10ml normal saline. Endotracheal intubation will be attempted and hemodynamic changes and adverse effects will be noted in each group, before, just after intubation and also at 1,3,5,10 minutes after intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-20
• Last Update Posted: 2021-11-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Patients of either sex Patients with ASA physical grade I or II Patients with age group 18 to 60 years undergoing elective surgery under general anesthesia Patients willing to give written consent.

Exclusion Criteria

Patients refusal Anticipated difficult airway (mallampati score >III, thyromental distance <6.5cm) Patients with diabetes and hypertension Pregnant or breast feeding mother Patients with respiratory, cardiac,neurological,renal or liver diseases Patients with gastro-oesophageal reflux Patients with known allergy to drugs used for induction of anaesthesia Psychiatric patients.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare efficacy of dexmedetomidine and magnesium sulphate on the attenuation of stress response of laryngoscopy and intubation in patients undergoing general anaesthesia.	Baseline | Before intubation, just after intubation ,and also at 1,3,5,10 minutes after intubation.

Secondary Outcome Measures

Name	Time	Method
To compare between dexmedetomidine and magnesium sulphate, a better drug for controlling the stress response.	Baseline

Trial Locations

Locations (1)

Regional Institute of Medical Sciences; 🇮🇳 West, MANIPUR, India

Regional Institute of Medical Sciences

🇮🇳West, MANIPUR, India

Yangchen Bhutia

Principal investigator

7908184386

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