Effects of Dietary Nitrate on Age-related Vascular Function

Phase 1

Completed

• Conditions: Endothelial Dysfunction
• Interventions: Dietary Supplement: Nitrate; Dietary Supplement: Placebo

• Registration Number: NCT01729234
• Lead Sponsor: Heinrich-Heine University, Duesseldorf

Brief Summary

Purpose of the study is to characterize the chronic effect of dietary nitrate on vascular function in healthy volunteers with particular emphasis on age-related alterations.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2012-11-14
• Study First Submitted QC: 2012-11-14
• Study First Posted: 2012-11-20
• Primary Completion: 2013-05
• Study Completion: 2013-05
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-06
• Last Update Posted: 2013-12-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

>55 Years Healthy

Exclusion Criteria

known cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Nitrate	Nitrate	150µmol /Kg bodyweight /day
PLacebo	Placebo	150µmol /Kg bodyweight /day

Primary Outcome Measures

Name	Time	Method
Endothelial function measured by flow-mediated dilation (FMD)	30 days	The effect of dietary nitrate on endothelial function as measured by flow-mediated dilation (FMD) after forearm ischemia and reperfusion.

Trial Locations

Locations (1)

Heinrich-Heine-University; 🇩🇪 Duesseldorf,, Nrw,, Germany