Prospective Athlete's Heart Study

Recruiting

• Conditions: Athlete Heart
• Interventions: Other: No intervention

• Registration Number: NCT05164328
• Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Brief Summary

The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-06-23
• Status Verified: 2021-12
• Study First Submitted: 2021-12-07
• Study First Submitted QC: 2021-12-07
• Last Update Submitted: 2021-12-07
• Study First Posted: 2021-12-20
• Last Update Posted: 2021-12-20
• Primary Completion: 2035-06-23
• Study Completion: 2040-06-23

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

1. Males and females aged 14-23 years old

2. Athletes competing in endurance sports at national or international level for at least 2 years. Sports include:

   1. Triathlon
   2. Cycling
   3. Distance running (≥ 1500 meters)
   4. Rowing
   5. Swimming

3. Non athletes engaged in < 3 hours per week of physical activity

Exclusion Criteria

1. Medical history of cardiovascular disease
2. Current smoker of past history of smoking
3. Diabetes mellitus

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Athletes	No intervention	1. Males and females aged 14-23 years old 2. Athletes competing in endurance sports at national or international level for at least 2 years. Sports include: 1. Triathlon 2. Cycling 3. Distance running (≥ 1500 meters) 4. Rowing 5. Swimming
Non-athletes	No intervention	1. Males and females aged 14-23 years old 2. Non athletes engaged in \< 3 hours per week of physical activity

Primary Outcome Measures

Name	Time	Method
Genotype	Baseline	Rare and common variants in cardiomyopathy associated genes
Atrial fibrillation	Baseline to 20 years
Ventricular arrhythmias	Baseline to 20 years	Ventricular ectopic beats, non-sustained and sustained ventricular tachycardia
Training load	Baseline to 20 years	Duration and intensity of training

Trial Locations

Locations (4)

Jessa Ziekenhuis Hasselt; 🇧🇪 Hasselt, Limburg, Belgium

Baker Heart and Diabetes Institute; 🇦🇺 Melbourne, Victoria, Australia

UZ Antwerpen; 🇧🇪 Edegem, Antwerp, Belgium

UZ Leuven; 🇧🇪 Leuven, Vlaams Brabants, Belgium