Clinical study to evaluate the effect of Virechan Karma in Oxidative Stress w.s.r. to Jara Kricchen Labhte
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- To evaluate the efficacy of Virechan karma in the
研究概览
简要总结
Acharya Charaka mentioned in the indication of Shodhan Chikitsa that Jara can be delayed by
administration of Shodhan chikitsa (Ch.Su.16/18) Acharya Charaka mentioned that before
administration of Rasayana, Shodhan should be done. Therefore, we have selected Virechan Karma
for this study. (Ch. K. 1/4; Ch.Chi.1/1/24)
Modern lifestyle associated with processed food, incompatible food (Virudh Aahar), exposure to a
wide range of chemicals & lack of physical activity due to advancement of science and technology,
in long run all these factors can affect metabolic activity significantly. When body internal system
fails to make balance between production and elimination of metabolic wastes (oxidized products of
free radicals) at cellular level than body land into state of oxidative stress.
O xidative stress has a role in a number of age-related disorders, including cancer, chronic renal
disease, chronic obstructive pulmonary disease, and cardiovascular diseases (CVDs). Ageing is
among the greatest known risk factors for most human diseases.
Thus this study aims to evaluate the effect of Virechan karma on Agni, Indriyaprasadan, Manas-
Buddhi, Varna, Bala, Vrishayta, Asyaprasadan, Lipid profile, BMI, Protein level,albumin and AG
ratio, S. Calcium and Bio marker of oxidative stress and antioxidant activity i.e MDA
(malondialdehyde) and GTH ( glutathione) respectively.
30 healthy volunteers will be selected as per Inclusion and Exclusion criteria.
It will be an open trial. Selected volunteers will be divided randomly into two
groups of 15 patients each.
Group A will be managed with
-
Deepan Pachan with Trikatu churan for 3 days
-
Snehpana with Murchit Goghritta will be done for 3-7 days in increasing pattern depending upon
Koshtha and Agni of the individual till the appearance of Samayak Snehpana Lakshana.
-
Sarvang Abhyang with Murchit Til Tail will be performed followed by Sarvanga Swedana.
-
Virechan Karma
-
Samsarjan krama
Group B will be managed with
Placebo of corn starch will be given in the capsule form of 500 mg in dose of 1
BD for the period of 18 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Volunteers fit for Virechan karma Volunteers who sign the consent form for Virechan karma.
排除标准
- •Volunteers contraindicated for Virechan Karma as per classics Volunteers below 18 years and above 60 years of age Volunteers having any associated chronic ailments like Tuberculosis, uncontrolled Hypertension, uncontrolled Diabetes Mellitus, and Malignancy.
- •Pregnant women and lactating mothers.
结局指标
主要结局
To evaluate the efficacy of Virechan karma in the
时间窗: To check the efficacy of Virechan karma in the | oxidative stress | To evaluate the effect of Virechan karma on Agni, | Indriyaprasadan, ManasBuddhi, Varna, Bala, | Vrishayta, Asyaprasadan, Lipid profile, BMI, | Protein level, | albumin and AG ratio, S. Calcium
oxidative stress
时间窗: To check the efficacy of Virechan karma in the | oxidative stress | To evaluate the effect of Virechan karma on Agni, | Indriyaprasadan, ManasBuddhi, Varna, Bala, | Vrishayta, Asyaprasadan, Lipid profile, BMI, | Protein level, | albumin and AG ratio, S. Calcium
To evaluate the effect of Virechan karma on Agni,
时间窗: To check the efficacy of Virechan karma in the | oxidative stress | To evaluate the effect of Virechan karma on Agni, | Indriyaprasadan, ManasBuddhi, Varna, Bala, | Vrishayta, Asyaprasadan, Lipid profile, BMI, | Protein level, | albumin and AG ratio, S. Calcium
Indriyaprasadan, ManasBuddhi, Varna, Bala,
时间窗: To check the efficacy of Virechan karma in the | oxidative stress | To evaluate the effect of Virechan karma on Agni, | Indriyaprasadan, ManasBuddhi, Varna, Bala, | Vrishayta, Asyaprasadan, Lipid profile, BMI, | Protein level, | albumin and AG ratio, S. Calcium
Vrishayta, Asyaprasadan, Lipid profile, BMI,
时间窗: To check the efficacy of Virechan karma in the | oxidative stress | To evaluate the effect of Virechan karma on Agni, | Indriyaprasadan, ManasBuddhi, Varna, Bala, | Vrishayta, Asyaprasadan, Lipid profile, BMI, | Protein level, | albumin and AG ratio, S. Calcium
Protein level,
时间窗: To check the efficacy of Virechan karma in the | oxidative stress | To evaluate the effect of Virechan karma on Agni, | Indriyaprasadan, ManasBuddhi, Varna, Bala, | Vrishayta, Asyaprasadan, Lipid profile, BMI, | Protein level, | albumin and AG ratio, S. Calcium
albumin and AG ratio, S. Calcium
时间窗: To check the efficacy of Virechan karma in the | oxidative stress | To evaluate the effect of Virechan karma on Agni, | Indriyaprasadan, ManasBuddhi, Varna, Bala, | Vrishayta, Asyaprasadan, Lipid profile, BMI, | Protein level, | albumin and AG ratio, S. Calcium
次要结局
- To explore literature about jara and effect of(virechan karma in oxidative stress with special)
研究者
Prof Anil Bhardwaj
Rajiv Gandhi Government Postgraduate Ayurvedic College and Hospital Paprola