Increasing plasma adrenaline levels through breathing techniques - an explorative study

Completed

Conditions: RA
10003816
reumatoid arthritis

Registration Number: NL-OMON41858

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 36

Inclusion Criteria

- Age >=18 and <=35 yrs
- Male
- Healthy

Exclusion Criteria

- Experience with the methods of Wim Hof and his team or other breathing techniques
- Use of any medication
- Smoking
- Use of recreational drugs within 21 days prior to the experiment day
- Use of caffeine or alcohol within 1 day prior to the experimental day.
- Surgery or trauma with significant blood loss or blood donation within 3 months prior to the experimental day.
- Participation in another clinical trial within 3 months prior to the experimental day.
- History, signs, or symptoms of cardiovascular disease
- History of atrial or ventricular arrhythmia
- Hypertension (RR systolic >160 or RR diastolic >90)
- Hypotension (RR systolic <100 or RR diastolic <50)
- Conduction abnormalities on the ECG consisting of a 1st degree atrioventricular block or a complex bundle branch block
- History of asthma
- CRP > 20 mg/L, WBC > 12x109/L, or clinically significant acute illness, including infections, within 4 weeks before the experimental day.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is plasma adrenaline concentration. Our primary<br /><br>endpoint is the difference between plasma adrenaline levels during the<br /><br>hyper/hypoventilation technique and the strength ventilation technique within<br /><br>the HTR group. </p><br>

Secondary Outcome Measures