Aminoacidemia and Protein Kinetics in Response to the Ingestion of Plant-based Protein Blends
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Muscle protein synthesis
研究概览
简要总结
The present investigation aims to study a novel plant based protein isolate blend to determine if it results in similar muscle building responses compared to whey protein isolate.
详细描述
Whey protein is considered the 'gold standard' to maintain body proteins (muscle, skin, bone). When isolated from milk, whey protein isolate (WPI) contains all nine essential amino acids (EAA) which are 'building blocks' that are needed to support the maintenance of body proteins. To date, there is no plant-based protein (PBP) isolate that compares to the recommended WPI towards how our body builds or supports our muscles. WPI is considered the 'gold standard' because it contains all of the EAA which provide the right amount of 'building blocks' to support our muscles. Current PBP isolates available contain insufficient amounts of EAA, and are less digestible, resulting in less 'building blocks' available to support our muscles. Recently, plant protein combinations have been designed to provide the right amounts of all the EAAs. Therefore, the aim of the present study is to determine the effects of a novel PBP blend on muscle protein synthesis responses by comparing it to WPI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
The study design will be a randomized, double blind, crossover trial.
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female, between the ages of 18 - 30 years (inclusive)
- •Have a body mass index (BMI) between 18-30 kg·m2 (inclusive)
- •Be in general good health as assessed by a general health questionnaire
- •Non-smoking
- •Regular menstrual cycle and not using hormonal contraceptives
- •Willing and able to provide informed consent
排除标准
- •Currently using analgesic or anti-inflammatory drugs
- •A history of neuromuscular problems or muscle and/or bone wasting diseases
- •Any acute or chronic illness, metabolic disorders
- •Currently using corticosteroids
- •Use of hormonal contraceptives or anabolic steroids (e.g. testosterone)
研究组 & 干预措施
Whey protein isolate
Whey protein isolate is the 'gold standard' of protein supplements due to being rich in essential amino acids and leucine. Leucine is a key amino acid the is required to stimulate muscle protein synthesis. Muscle protein synthesis is the major mechanism the underpins muscle growth. The whey protein would ostensibly serve as a positive control.
干预措施: Protein quality (Dietary Supplement)
Plant based protein isolate
Current plant-based protein isolates available contain insufficient amounts of leucine, and are less digestible, resulting in a reduced muscle protein synthesis responses. The plant based protein would ostensibly serve as a negative control.
干预措施: Protein quality (Dietary Supplement)
Plant based protein isolate + leucine
Enriching plant-based protein with leucine will increase the 'quality' of said protein source and theoretically should have similar muscle protein synthetic responses to whey protein.
干预措施: Protein quality (Dietary Supplement)
结局指标
主要结局
Muscle protein synthesis
时间窗: Over a 5 hour period
A marker of muscle growth
次要结局
- Questionnaire on safety(Over a 5 hour period)
- Palatability of test drinks(Immediately after test drink are consumed.)
- Aminoacidemia(Over a 5 hour period)
- Appetite and desire for specific food types in response to test drinks types H(Immediately before, and 30, 60, 120, 180 and 300 minutes after test drinks are consumed.)
- Tolerability of test drinks(Over a 5 hour period)
研究者
Stuart Phillips
Professor
McMaster University