Screening for colorectal cancer in the Netherlands;a study comparing attendance and feasibility of two different forms of faecal occult blood testing and sigmoidoscopy.
Recruiting
- Conditions
- 1. Colorectal cancer<br />2. screening<br />3. attendance.
- Registration Number
- NL-OMON25308
- Lead Sponsor
- Initiator: Erasmus MC, University Medical Center RotterdamDepartment of Gastroenterology and hepatology
- Brief Summary
Manuscript in progress.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 15000
Inclusion Criteria
1. 50-75 year old;
2. Ability to provide informed consent.
Exclusion Criteria
1. Inability or refusal to provide informed consent;
2. History of colorectal cancer, adenomas, inflammatory bowel disease*;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Attendance for CRC screening with guaiac based FOBT (Haemoccult II), immunochemical FOBT (OC-Hemodia Latex) and sigmoidoscopy.
- Secondary Outcome Measures
Name Time Method 1. The diagnostic yield of FOBT screening and sigmoidoscopy based screening in the Netherlands;<br /><br>2. The feasibility and required capacity for primary sigmoidoscopy CRC screening in our country;<br /><br>3. The feasibility and required colonoscopy capacity needed for further evaluation of participants with a positive screening test in relation to the initial screening method used;<br /><br>4. Side effects of screening;<br /><br>5. Participants experiences; the acceptability, satisfaction and burden of screening (FOBT or sigmoidoscopy);<br /><br>6. Identification of optimal choices for implementation of a CRC screening program (process evaluation);<br /><br>7. Comparison of the cost-effectiveness ratio of the two forms of FOBT and sigmoidoscopy in CRC screening.