Study on the Effectiveness of "Treatment Regulation Mode" Based on Neuromodulation and Electronic Follow-up to Reduce Relapse Behavior in Patients With Substance Dependence
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Change from Baseline cue-induced craving at 2 weeks
Study Overview
Brief Summary
Transcranial direct current stimulation (tDCS) combined with computerized cognitive addiction therapy(CCAT) for methamphetamine(MA) dependent patients in voluntary drug rehabilitation center. Electronic medical systems were applied for drug related knowledge education, self-evaluation and outpatient follow-up reminder after intervention in order to reduce relapse behaviors.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Methamphetamine dependent patients with normal eyesight and hearing.
Exclusion Criteria
- •any diagnosis of DSM-IV axis I diseases.
- •any physical diseases which might influence cognitive function such as epilepsy, cerebrovascular disease or brain injury.
- •negative behaviors or harm to others.
- •cognitive enhance drug use history in last 6 months.
- •other drug dependence(except nicotine).
Arms & Interventions
True tDCS Combined With CCAT
Ture transcranial direct current stimulation (tDCS) intervention combined with computerized cognitive addiction therapy(CCAT) group, last 25 minutes per day for 4 weeks(5 days/week). Electronic follow-up for 6 month including drug knowledge every week, self-evaluation every two weeks and outpatient follow-up reminder every four weeks.
Intervention: Ture Transcranial Direct Current Stimulation (tDCS) (Device)
Sham tDCS Combined With CCAT
Sham transcranial direct current stimulation (tDCS) intervention combined with computerized cognitive addiction therapy(CCAT) group, last 25 minutes per day for 4 weeks(5 days/week). Electronic follow-up for 6 month including only outpatient follow-up reminder every four weeks.
Intervention: Sham Transcranial Direct Current Stimulation (tDCS) (Device)
Control group
During the treatment, the participants in control group only received treatment such as education of psychology, health and judicature, physical training as well as vocational training as usual in the compulsory rehabilitation center.
Outcomes
Primary Outcomes
Change from Baseline cue-induced craving at 2 weeks
Time Frame: 2 weeks
Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being "no craving"and 100 mm representing "most craving ever experienced for methamphetamine".
Change from Baseline cue-induced craving at 4 weeks
Time Frame: 4 weeks
Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being "no craving"and 100 mm representing "most craving ever experienced for methamphetamine".
Secondary Outcomes
- response inhibition function(2 weeks，4 weeks)
- cognitive function(2 weeks，4 weeks)
- Attention bias towards methamphetamine(2 weeks，4 weeks)
- reward-related function(2 weeks，4 weeks)