ew Therapies for bone and cartilage defects using bone marrow
Recruiting
- Conditions
- not applicable1002321310046304
- Registration Number
- NL-OMON43408
- Lead Sponsor
- Orthopaedie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
undergoing total hip replacement surgery
Exclusion Criteria
had radiation therapy in the hip area
haematologic disorders (such as leukemia or hemophilia)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>First the cells of interest will be isolated from the bone marrow biopsy and<br /><br>then subjected to a series of culture and analyses methods. The exact methods<br /><br>will depend on the research question. We will characterize the cells using FACS<br /><br>analyses and evaluate the capacity to form bone or cartilage using histology,<br /><br>mRNA and protein analyses. Furthermore the capacity of the cells to inhibit<br /><br>inflammation will be evaluated in the laboratory by bringing them in contact<br /><br>with immune cells. All research is aimed to find methods to improve the<br /><br>treatment of cartilage and bone defects. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>