“A Randomized clinical trial to evaluate the efficacy of Ayurveda Interventions as an add on therapy on functional, cardiac autonomic and cortical excitability measures in ambulant patients with Duchenne Muscular Dystrophy (Mamsa medagata vata)â€

This study is a randomized clinical trial toevaluate the efficacy of Ayurveda interventions as an add-on therapy inpatients with Duchenne Muscular Dystrophy comparing with the conventionaltreatment alone and explore the utility of neurophysiologic investigations inprognostication. This study hypothesized that Ayurveda interventions as anadd-on therapy would improve the clinical, functional, cardiac autonomicfunctions, cortical excitability measures and serum creatinine kinase markersmore than the conventional treatment in Duchenne Muscular Dystrophy. TheAyurveda interventions Sanjivani vati, Ashwagandha choorna, Dhanwantharam taila101 A will be given internally and Ksheerabala taila will be given for abhyanga(external oil application) and matravasti (oil enema in small dose). Theprimary outcome measures are functional measures and ayurveda rating scales.Secondary outcome measures are heart rate variability (HRV), echocardiography, transcranialmagnetic stimulation (TMS), serum creatinine kinase levels and quality of lifeusing PedsQL 3.0 DMD Module. Monthly follow ups will be done for 3 months ofintervention period and one month after treatment. The primary end point willbe at 2 months of intervention period.