Comparison of the Effects of Three Single Pill Combinations of two drugs Therapies on Aortic Stiffness and Central Arterial Pressure in Patients with hypertension

Imperial College of London0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年9月18日

试验速览

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•1. Patients with Sitting clinic values of Systolic blood pressure between 140 mmHg and 160 mmHg on one antihypertensive agent OR
•2. Patient with Sitting clinic values of Systolic Blood Pressure between 150 mmHg and 180 mmHg on no antihypertensive treatment

•1. Congestive heart failure (clinically defined).
•2. Patients with a history of intolerance to any of the study medications for example angioedema or dry cough with ACE-inhibitors.
•3. Serum creatinine levels greater than 132.6 µmol/l (1.5mg/dl)
•4. History of coronary heart disease (i.e chronic stable angina, myocardial infarction or acute coronary syndrome).
•5. History of a stroke or other cerebrovascular accident (i.e. transient ischaemic attack or reversible ischaemic neurological deficit).
•6. Severe hepatic impairment
•7. Treatment with agents causing torsades de pointes
•8. Lactation
•9. Contraindications to any of the investigational medicinal products as per the SmPc of drugs studied
•10. Known or suspected secondary hypertension.
•11. Any other concomitant illness, physical or mental impairment that could interfere with the effective conduct of the study.
•12. Pregnancy or those of child-bearing age who are not taking reliable contraception.
•13. History of Gout.
•14. Serum potassium less than 3.5mmol/L at screening.

发起方

Imperial College of London