Prevention of Ventilator Associated Pneumonia With Toothbrushing in Oral Care of Critically Ill Mechanically Ventilated Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,030
- 试验地点
- 1
- 主要终点
- Nosocomial ventilator associated pneumonia
研究概览
简要总结
Effect of toothbrushing in oral care of mechanically ventilated critically ill patients on prevention of ventilator associated pneumonia
详细描述
Prospective, before and after study in 5 Intensive Care Units (ICUs) of a university hospital.
The before period (control phase, 6 months): standard oral care 3 times a day in every consecutive intubated patients in the participating ICUs The interphase period (1 month): formal training of all the nurses, physicians and residents on the use of toothbrushing during oral care The after period: (study phase, 6 months): standard oral care with tooth brushing 3 times a day in every consecutive intubated patients in the participating ICUs
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients
- •Intubated mechanically ventilated ICU patient
- •Platelets count >50G/L
排除标准
- •Edentulous patients
结局指标
主要结局
Nosocomial ventilator associated pneumonia
时间窗: at Day-28
Presence of at least two signs (body fever greater than 38°C; leukocytosis greater than 12000/ml or leukopenia below 4000/ml, purulent pulmonary secretions) associated with the appearance of a new infiltrate or modification of an existing infiltrate on chest-X-ray. Confirmation by a lower respiratory tract sample using a quantitative culture with a predefined positive threshold. Hospital-acquired pneumonia was defined as a pneumonia that occurs at least 48 hours after admission, which was not incubating at time of admission (Am J Respir Crit Care Med 2005; 171, 388-416).
次要结局
- Hospital mortality(at Day-90)
- ICU length of stay(at Day-90)
- ICU mortality(at Day-90)
- Tracheobronchitis(at Day-28)
- Antibiotic free days(at Day-90)