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Clinical Trials/NCT01671917
NCT01671917
Completed
N/A

Evaluation of an Educational Program Associated With Exercises (EDEX) Before Total Knee Arthroplasty

Assistance Publique - Hôpitaux de Paris1 site in 1 country262 target enrollmentOctober 4, 2012

Overview

Phase
N/A
Intervention
Not specified
Conditions
Knee Osteoarthritis
Sponsor
Assistance Publique - Hôpitaux de Paris
Enrollment
262
Locations
1
Primary Endpoint
The percentage of patients able to quit independently the orthopedic department
Status
Completed
Last Updated
7 months ago

Overview

Brief Summary

The purpose of this study is to determine whether a standardized education and exercise program proposed before a total knee replacement for knee osteoarthritis is effective in functional recovery after surgery.

Detailed Description

Knee osteoarthritis leads to deficiencies in muscle strength, knee range of motion and balance, and cardio respiratory deconditioning that contribute to alter abilities to perform activities of daily living. It is the principal indication for total knee arthroplasty (TKA). Patients' functional state and pain level are generally improved after TKA and the physical and functional status pre-TKA are predictive of recovery after surgery. Decreasing length of stay at surgery departments and promoting return at home after TKA are recommended. The recommendations of the Health Authority in France (HAS) and the new law of finance for French clinics contribute to shorter hospital stays and to restrain the conditions of admission to Physical Medicine and Rehabilitation department after TKA.Exercise and education programs conducted before TKA could help better prepare patients for surgery, improve functional outcome and accelerate functional recovery after surgery thus reducing the length of stay in orthopedic departments and facilitate return to home (directly or after a stay in PMR departments). The type of program necessary to achieve those goals remains to be defined.A systematic review of the literature associated with an analysis of practices about the relevance of rehabilitation programs before TKA, concluded that the implementation of such programs before TKA was likely to reduce the length of stay in surgery departments and improve the rate of direct return to home after surgery but that high quality trials were lacking. It also suggested that association of exercise programs with educational ones could be more effective than exercise or education alone, particularly for fragile patients with impaired functional capacity, co-morbidities and/or social problems.

Registry
clinicaltrials.gov
Start Date
October 4, 2012
End Date
November 29, 2017
Last Updated
7 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Male or female aged 50 to 85 years
  • Patient suffering from knee osteoarthritis according to ACR for which a total knee arthroplasty is scheduled
  • Preliminary medical examination whose results will be transmitted to the patient
  • Patient giving his informed consent to participate in the study
  • Patient affiliated to or beneficiary of social insurance

Exclusion Criteria

  • Patients institutionalized
  • Patients who have already received an ipsilateral total knee arthroplasty
  • Patients with chronic inflammatory arthritis
  • Cognitive or behavioral disorders making assessment impossible
  • Inability to speak and write French
  • TKA indicated for other reason than osteoarthritis

Outcomes

Primary Outcomes

The percentage of patients able to quit independently the orthopedic department

Time Frame: at day 4 post-surgery

Assessed by the ability to perform lying-sitting and sitting-standing transfers, walk 30 meters and go up and down one floor at day 4 (± 1 day) after the surgery. Each item will be scored on a 4-class scale (0, unable to perform and 3, able to perform independently). Ability to quite the orthopedic department will be defined as scoring 3 out of 3 for all 4 assessed items on the day of discharge from the orthopedic department.

Changes from baseline in functional recovery

Time Frame: 6 months post-surgery

Assessed by the area under the curve of the function subscale of the WOMAC index within the first 6 months post-surgery

Secondary Outcomes

  • Changes from baseline in mean knee pain in the previous 48 hrs(12 months post-surgery)
  • Changes from baseline in mean function in the previous 48 hrs(12 months post-surgery)
  • Changes from baseline in the mean number of steps in the previous week(12 months post-surgery)
  • Satisfaction with the treatment(12 months months post-surgery)
  • Changes from baseline in mean quality of life(12 months post-surgery)
  • Cost-effectiveness(12 months months post-surgery)
  • Adverse events(12 months post-surgery)

Study Sites (1)

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