跳至主要内容
临床试验/NCT01825304
NCT01825304Unknown4 期

the Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation

Nanjing Medical University2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2011年10月1日最近更新:
适应症

试验速览

阶段
4 期
发起方
入组人数
60
试验地点
2
主要终点
ventilator-free days

研究概览

简要总结

Intra-abdominal hypertension can increase the pleural pressure, and then end-expiratory transpulmonary pressures will be turn to negative, Pulmonary atelectasis/acute lung injury/acute respiratory distress syndrome will appear. In the group of people who suffering intra-abdominal hypertension, the investigators use the pressure of esophagus to speculate the Intrathoracic pressure, and to setting PEEP in order to decrease the happening of ALI/ARDS, which may decrease morbidity in this population.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Investigator)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • intra-abdominal hypertension
  • mechanical ventilation

排除标准

  • underlying pulmonary disease
  • age older than 60 years and younger than 18 years
  • vital signs were not stable
  • non voluntary

结局指标

主要结局

ventilator-free days

时间窗: 28d

Comparison of two groups the duration of ventilation-free in 28d,ventilator-free day include weaning from mechanical ventilation more than 24h.

次要结局

  • mortality(28d)

研究者

发起方
Nanjing Medical University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Gang Li

PLA Research Institute of general surgery

Nanjing Medical University

研究点 (2)

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