Positive End-expiratory Pressure and Esophageal Catheter Optimal Calibration Volume in ARDS Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- transpulmonary pressure measured estimating pleural pressure through the esophageal balloon
研究概览
简要总结
The use of esophageal balloon catheter to estimate pleural pressure has gained renewed popularity in recent years. Indeed, measurement of transpulmonary pressure may allow a more pathophysiological-based approach to ventilator strategy in acute respiratory distress syndrome (ARDS) patients. Nevertheless, it is well known that esophageal balloon catheter derived parameters can be influenced by several patient-related or technical-related factors.
During a PEEP trial, the investigators will observe in-vivo the esophageal pressure and derived measurements obtained using different esophageal balloon calibration volumes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of ARDS with a PEEP of at least 8 cmH2O
- •Fraction of inspired oxygen not higher than 80%
- •Intubated and ventilated in Volume Control Ventilation mode set by the attending physician according to clinical criteria
- •Need of continuous sedation through intravenous anesthetics and full neuromuscular blockade
排除标准
- •Been pregnant or breastfeeding
- •Hemodynamic instability
- •Presence of tracheobronchial fistula
- •Known pneumothorax
- •Leak in airway circuitry
- •Presence of any kind of inhalator therapy (e.g. Heliox, nitric oxide, anesthetic conserving device)
- •Recent history of nasal trauma or lesion of nasal cavity
- •Recent history of esophageal, gastrointestinal, ENT, thoracic or cardiac surgery (less than 2 months)
- •Known or suspected esophageal varices
- •Congenital, acquired or drug-induced hemostatic disorder
- •Thrombocytopenia (less than 50000/mm3)
- •Recent history of Traumatic Brain Injury or thoraco-abdominal trauma (less than 1 months)
- •Rib or sternal fractures
结局指标
主要结局
transpulmonary pressure measured estimating pleural pressure through the esophageal balloon
时间窗: within 10 minutes after esophageal balloon volume changing
次要结局
- End-expiratory lung volume(within 60 minutes after PEEP changing)
研究者
Magni Federico
UOC Anestesia e Rianimazione ASST Monza
San Gerardo Hospital