Positive End-expiratory Pressure and Esophageal Catheter Optimal Calibration Volume in ARDS Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ARDS
- Sponsor
- Magni Federico
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- transpulmonary pressure measured estimating pleural pressure through the esophageal balloon
- Last Updated
- 9 years ago
Overview
Brief Summary
The use of esophageal balloon catheter to estimate pleural pressure has gained renewed popularity in recent years. Indeed, measurement of transpulmonary pressure may allow a more pathophysiological-based approach to ventilator strategy in acute respiratory distress syndrome (ARDS) patients. Nevertheless, it is well known that esophageal balloon catheter derived parameters can be influenced by several patient-related or technical-related factors.
During a PEEP trial, the investigators will observe in-vivo the esophageal pressure and derived measurements obtained using different esophageal balloon calibration volumes.
Investigators
Magni Federico
UOC Anestesia e Rianimazione ASST Monza
San Gerardo Hospital
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of ARDS with a PEEP of at least 8 cmH2O
- •Fraction of inspired oxygen not higher than 80%
- •Intubated and ventilated in Volume Control Ventilation mode set by the attending physician according to clinical criteria
- •Need of continuous sedation through intravenous anesthetics and full neuromuscular blockade
Exclusion Criteria
- •Been pregnant or breastfeeding
- •Hemodynamic instability
- •Presence of tracheobronchial fistula
- •Known pneumothorax
- •Leak in airway circuitry
- •Presence of any kind of inhalator therapy (e.g. Heliox, nitric oxide, anesthetic conserving device)
- •Recent history of nasal trauma or lesion of nasal cavity
- •Recent history of esophageal, gastrointestinal, ENT, thoracic or cardiac surgery (less than 2 months)
- •Known or suspected esophageal varices
- •Congenital, acquired or drug-induced hemostatic disorder
Outcomes
Primary Outcomes
transpulmonary pressure measured estimating pleural pressure through the esophageal balloon
Time Frame: within 10 minutes after esophageal balloon volume changing
Secondary Outcomes
- End-expiratory lung volume(within 60 minutes after PEEP changing)